Cheung Michael Lok Man, Kan Monica Wk, Yeung Vanessa Ty, Poon Darren Mc, Kam Michael Km, Lee Louis Ky, Chan Anthony Tc
State Key Laboratory of Translational Oncology, The Chinese University of Hong Kong, Hong Kong, SAR, China.
BJR Open. 2021 Nov 24;3(1):20210041. doi: 10.1259/bjro.20210041. eCollection 2021.
To retrospectively analyze the clinical impact on stereotactic body radiation therapy (SBRT) for hepatocellular carcinoma (HCC) located at lung-liver boundary due to the use of Acuros XB algorithm (AXB) in replacement of anisotropic analytical algorithm (AAA).
23 SBRT volumetric modulated arc therapy (VMAT) plans for HCC located at lung-liver boundary were calculated using AAA and AXB respectively with the same treatment parameters. The dose-volume data of the planned target volumes (PTVs) were compared. A published tumour control probability (TCP) model was used to calculate the effect of dosimetric difference between AAA and AXB on tumour control probability.
For dose calculated by AXB (Dose to medium), the D95% and D98% of the PTV were on average 2.4 and 3.1% less than that calculated by AAA. For dose calculated by AXB (dose to water), the D95% and D98% of the PTV were on average 1.8%, and 2.7% less than that calculated by AAA. Up to 5% difference in D95% and 8% difference in D98% were observed in the worst cases. The significant decrease in D95% calculated by AXB compared to AAA could result in a % decrease in 2 year TCP up to 8% in the worst case (from 46.8 to 42.9%).
The difference in dose calculated by AAA and AXB could lead to significant difference in TCP for HCC SBRT located at lung-liver boundary region.
The difference in calculated dose and tumour control probability for HCC SBRT between AAA and AXB algorithm at lung-liver boundary region was compared.
回顾性分析在立体定向体部放射治疗（SBRT）中，用Acuros XB算法（AXB）替代各向异性解析算法（AAA）对位于肺肝交界的肝细胞癌（HCC）的临床影响。
分别使用AAA和AXB，在相同治疗参数下计算23例位于肺肝交界的HCC的SBRT容积调强弧形治疗（VMAT）计划。比较计划靶区（PTV）的剂量体积数据。使用已发表的肿瘤控制概率（TCP）模型计算AAA和AXB之间剂量差异对肿瘤控制概率的影响。
对于AXB计算的剂量（介质剂量），PTV的D95%和D98%平均比AAA计算的剂量低2.4%和3.1%。对于AXB计算的剂量（水剂量），PTV的D95%和D98%平均比AAA计算的剂量低1.8%和2.7%。在最糟糕的情况下，观察到D95%有高达5%的差异，D98%有高达8%的差异。与AAA相比，AXB计算的D95%显著降低，在最糟糕的情况下可能导致2年TCP降低高达8%（从46.8%降至42.9%）。
AAA和AXB计算的剂量差异可能导致位于肺肝交界区域的HCC的SBRT的TCP有显著差异。
比较了AAA和AXB算法在肺肝交界区域HCC的SBRT中计算剂量和肿瘤控制概率的差异。
