阻塞性肺疾病中的基底膜。

Basement membranes in obstructive pulmonary diseases.

作者信息

Dekkers Bart G J, Saad Shehab I, van Spelde Leah J, Burgess Janette K

机构信息

University of Groningen, University Medical Center Groningen, Department of Clinical Pharmacy and Pharmacology, Groningen, The Netherlands.

University of Groningen, University Medical Center Groningen, Groningen Research Institute for Asthma and COPD (GRIAC), Groningen, The Netherlands.

出版信息

Matrix Biol Plus. 2021 Nov 12;12:100092. doi: 10.1016/j.mbplus.2021.100092. eCollection 2021 Dec.

DOI:10.1016/j.mbplus.2021.100092

PMID:34877523

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8632995/

Abstract

Increased and changed deposition of extracellular matrix proteins is a key feature of airway wall remodeling in obstructive pulmonary diseases, including asthma and chronic obstructive pulmonary disease. Studies have highlighted that the deposition of various basement membrane proteins in the lung tissue is altered and that these changes reflect tissue compartment specificity. Inflammatory responses in both diseases may result in the deregulation of production and degradation of these proteins. In addition to their role in tissue development and integrity, emerging evidence indicates that basement membrane proteins also actively modulate cellular processes in obstructive airway diseases, contributing to disease development, progression and maintenance. In this review, we summarize the changes in basement membrane composition in airway remodeling in obstructive airway diseases and explore their potential application as innovative targets for treatment development.

摘要

细胞外基质蛋白沉积的增加和改变是阻塞性肺疾病（包括哮喘和慢性阻塞性肺疾病）气道壁重塑的关键特征。研究强调，肺组织中各种基底膜蛋白的沉积发生了改变，且这些变化反映了组织区室特异性。这两种疾病中的炎症反应可能导致这些蛋白的产生和降解失调。除了在组织发育和完整性方面的作用外，新出现的证据表明，基底膜蛋白在阻塞性气道疾病中也积极调节细胞过程，促进疾病的发生、发展和维持。在本综述中，我们总结了阻塞性气道疾病气道重塑中基底膜组成的变化，并探讨了它们作为治疗开发创新靶点的潜在应用。