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1
Hyperglycemia in acute COVID-19 is characterized by insulin resistance and adipose tissue infectivity by SARS-CoV-2.急性新冠肺炎中的高血糖症表现为胰岛素抵抗以及严重急性呼吸综合征冠状病毒2对脂肪组织的感染性。
Cell Metab. 2021 Dec 7;33(12):2484. doi: 10.1016/j.cmet.2021.10.014.
2
Hyperglycemia in acute COVID-19 is characterized by insulin resistance and adipose tissue infectivity by SARS-CoV-2.急性新冠肺炎中的高血糖症表现为胰岛素抵抗以及严重急性呼吸综合征冠状病毒2对脂肪组织的感染性。
Cell Metab. 2021 Nov 2;33(11):2174-2188.e5. doi: 10.1016/j.cmet.2021.09.009. Epub 2021 Sep 16.
3
SARS-CoV-2 adipose tissue infection and hyperglycemia: A further step towards the understanding of severe COVID-19.严重急性呼吸综合征冠状病毒2型脂肪组织感染与高血糖：迈向理解重症新型冠状病毒肺炎的又一步。
Metabol Open. 2022 Mar;13:100163. doi: 10.1016/j.metop.2022.100163. Epub 2022 Jan 13.
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Effects of Weight Loss on Adipose and Muscular Neuropilin 1 mRNA Expression in Obesity: Potential Implication in SARS-CoV-2 Infections?减肥对肥胖症脂肪组织和肌肉神经纤毛蛋白 1 mRNA 表达的影响：对 SARS-CoV-2 感染的潜在影响？
Obes Facts. 2022;15(1):90-98. doi: 10.1159/000520419. Epub 2021 Dec 10.
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Gene Networks of Hyperglycemia, Diabetic Complications, and Human Proteins Targeted by SARS-CoV-2: What Is the Molecular Basis for Comorbidity?高血糖、糖尿病并发症与 SARS-CoV-2 作用的人类蛋白的基因网络：共病的分子基础是什么？
Int J Mol Sci. 2022 Jun 29;23(13):7247. doi: 10.3390/ijms23137247.
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Clinical Study of Hyperglycemia and SARS-CoV-2 Infection in Intensive Care Unit Patients.《重症监护病房患者高血糖与 SARS-CoV-2 感染的临床研究》
In Vivo. 2020 Sep-Oct;34(5):3029-3032. doi: 10.21873/invivo.12136.
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Extremely high-dose insulin requirement in a diabetic patient with COVID-19: a case report.新冠肺炎合并糖尿病患者极高剂量胰岛素需求：一例报告。
BMC Endocr Disord. 2020 Oct 16;20(1):155. doi: 10.1186/s12902-020-00632-2.
8
Hyperglycemia and Angiotensin-Converting Enzyme 2 in Pulmonary Function in the Context of SARS-CoV-2 Infection.2019冠状病毒病感染背景下高血糖与血管紧张素转换酶2对肺功能的影响
Front Med (Lausanne). 2022 Jan 13;8:758414. doi: 10.3389/fmed.2021.758414. eCollection 2021.
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Hyperglycemia and insulin resistance in COVID-19 versus non-COVID critical illness: Are they really different?2019冠状病毒病与非2019冠状病毒病危重症中的高血糖和胰岛素抵抗：它们真的有区别吗？
Crit Care. 2021 Dec 17;25(1):437. doi: 10.1186/s13054-021-03861-6.
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Effect of linagliptin plus insulin in comparison to insulin alone on metabolic control and prognosis in hospitalized patients with SARS-CoV-2 infection.比较利拉鲁肽联合胰岛素与单独胰岛素对住院 COVID-19 感染患者代谢控制和预后的影响。
Sci Rep. 2022 Jan 11;12(1):536. doi: 10.1038/s41598-021-04511-1.

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1
Increased Incidence of New-Onset Diabetic Retinopathy in Individuals with COVID-19 in an Underserved Urban Population in the Bronx.纽约市布朗克斯区一个服务欠缺的城市人口中，感染新冠病毒的个体新发糖尿病视网膜病变的发病率增加。
Diagnostics (Basel). 2025 Jul 22;15(15):1846. doi: 10.3390/diagnostics15151846.
2
Neuro-immune Interactions in Metabolic Regulation: Brain and Adipose Tissue Crosstalk.代谢调节中的神经-免疫相互作用：脑与脂肪组织的相互作用
J Obes Metab Syndr. 2025 Jul 30;34(3):182-195. doi: 10.7570/jomes25050. Epub 2025 Jul 25.
3
COVID-19 induces persistent transcriptional changes in adipose tissue that are not associated with Long COVID.新冠病毒病（COVID-19）会在脂肪组织中引发持续的转录变化，这些变化与长期新冠无关。
bioRxiv. 2025 May 27:2025.05.23.655815. doi: 10.1101/2025.05.23.655815.
4
Obesity-Induced Metabolic Priming Exacerbates SARS-CoV-2 Inflammation.肥胖诱导的代谢启动加剧了SARS-CoV-2炎症反应。
Immunology. 2025 Jul;175(3):323-338. doi: 10.1111/imm.13934. Epub 2025 Apr 23.
5
Changes in tumor and cardiac metabolism upon immune checkpoint.免疫检查点作用下肿瘤和心脏代谢的变化
Basic Res Cardiol. 2025 Feb;120(1):133-152. doi: 10.1007/s00395-024-01092-8. Epub 2024 Dec 10.
6
The prognostic significance of insulin resistance in COVID-19: a review.胰岛素抵抗在2019冠状病毒病中的预后意义：综述
J Diabetes Metab Disord. 2024 Jan 20;23(1):305-322. doi: 10.1007/s40200-024-01385-8. eCollection 2024 Jun.
7
Imatinib treatment improves hyperglycaemic dysregulation in severe COVID-19: a secondary analysis of blood biomarkers in a randomised controlled trial.伊马替尼治疗改善重症 COVID-19 的高血糖失调：一项随机对照试验中血液生物标志物的二次分析。
Crit Care. 2024 Feb 29;28(1):65. doi: 10.1186/s13054-024-04829-y.
8
SARS-CoV-2 Infection Alters the Phenotype and Gene Expression of Adipocytes.SARS-CoV-2 感染改变脂肪细胞的表型和基因表达。
Int J Mol Sci. 2024 Feb 8;25(4):2086. doi: 10.3390/ijms25042086.
9
The interplay of aging, adipose tissue, and COVID-19: a potent alliance with implications for health.衰老、脂肪组织和 COVID-19 的相互作用：一个强大的联盟，对健康有影响。
Geroscience. 2024 Jun;46(3):2915-2932. doi: 10.1007/s11357-023-01058-z. Epub 2024 Jan 8.
10
Aminoacyl-tRNA synthetase interactions in SARS-CoV-2 infection.SARS-CoV-2 感染中的氨酰-tRNA 合成酶相互作用。
Biochem Soc Trans. 2023 Dec 20;51(6):2127-2141. doi: 10.1042/BST20230527.

Hyperglycemia in acute COVID-19 is characterized by insulin resistance and adipose tissue infectivity by SARS-CoV-2.

作者信息

Reiterer Moritz, Rajan Mangala, Gómez-Banoy Nicolás, Lau Jennifer D, Gomez-Escobar Luis G, Ma Lunkun, Gilani Ankit, Alvarez-Mulett Sergio, Sholle Evan T, Chandar Vasuretha, Bram Yaron, Hoffman Katherine, Bhardwaj Priya, Piloco Phoebe, Rubio-Navarro Alfonso, Uhl Skyler, Carrau Lucia, Houhgton Sean, Redmond David, Shukla Alpana P, Goyal Parag, Brown Kristy A, tenOever Benjamin R, Alonso Laura C, Schwartz Robert E, Schenck Edward J, Safford Monika M, Lo James C

出版信息

Cell Metab. 2021 Dec 7;33(12):2484. doi: 10.1016/j.cmet.2021.10.014.

DOI:10.1016/j.cmet.2021.10.014
PMID:34879241
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8650200/
Abstract
摘要