Ministry of Education Key Laboratory of Environment and Health, and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, No.13 Hangkong Road, Wuhan 430030, China; Department of Maternal and Child Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, No.13 Hangkong Road, Wuhan 430030, China.
Center for Statistics in Medicine, NDORMS, The Botnar Research Centre, University of Oxford, Old Rd, Oxford OX3 7LD, UK.
J Affect Disord. 2022 Feb 15;299:233-238. doi: 10.1016/j.jad.2021.12.009. Epub 2021 Dec 5.
The present study aims to investigate the association between PM exposure and major depressive disorder, and to examine whether vitamin D and physical activity could attenuate the impact of PM on major depressive disorder.
39168 elderly adults (age≥60 years) who had valid estimates on exposure of PM in 2010 and data on major depressive disorder were extracted from the UK Biobank. Major depressive disorder was assessed by lifetime experience of mild, moderate, and severe major depression with validated instruments. Logistic regression models were used to estimate the association between PM exposure and major depressive disorder.
A total of 9079 participants had major depressive disorder, with a prevalence of 23.2%. The odds ratio (OR) of major depressive disorder was 1.096 (1.023, 1.175) for participants in the highest quartile compared with the lowest quartile of PM. The correlation of PM with major depressive disorder generally increased with the decreasing levels of vitamin D. For instance, in participants with the highest quartile of PM, the corresponding ORs were 1.141 (0.951, 1.369), 1.232 (1.027, 1.478), 1.286 (1.072, 1.543), and 1.390 (1.159, 1.667) for those who had adequate, desirable, insufficient, and deficient levels of vitamin D, respectively. Additionally, significant modification effects of physical activity on the relationship between PM and major depressive disorder were also observed.
Our study suggests that high levels of vitamin D and physical activity may attenuate the relationship between PM and major depressive disorder among elderly adults.
本研究旨在探讨 PM 暴露与重度抑郁症之间的关联，并检验维生素 D 和身体活动是否可以减轻 PM 对重度抑郁症的影响。
从英国生物银行中提取了 39168 名年龄≥60 岁的老年人（2010 年 PM 暴露值有效）和重度抑郁症数据。使用经过验证的工具评估终生轻度、中度和重度抑郁发作经历，来评估重度抑郁症。使用逻辑回归模型估计 PM 暴露与重度抑郁症之间的关联。
共有 9079 名参与者患有重度抑郁症，患病率为 23.2%。与 PM 最低四分位数的参与者相比，最高四分位数的参与者重度抑郁症的比值比（OR）为 1.096（1.023，1.175）。PM 与重度抑郁症的相关性通常随着维生素 D 水平的降低而增加。例如，在 PM 最高四分位数的参与者中，相应的 OR 分别为 1.141（0.951，1.369）、1.232（1.027，1.478）、1.286（1.072，1.543）和 1.390（1.159，1.667），对于维生素 D 充足、理想、不足和缺乏的参与者。此外，还观察到身体活动对 PM 和重度抑郁症之间关系的显著修饰作用。
我们的研究表明，高水平的维生素 D 和身体活动可能会减轻老年人 PM 与重度抑郁症之间的关系。
