日本儿童与接受基于柏林-法兰克福-慕尼黑（BFM）95 方案治疗的西方儿童急性淋巴细胞白血病患者的症状性骨坏死发生率相似。

The incidence of symptomatic osteonecrosis is similar between Japanese children and children in Western countries with acute lymphoblastic leukaemia treated with a Berlin-Frankfurt-Münster (BFM)95-based protocol.

机构信息

Department of Pediatrics, Tohoku University Graduate School of Medicine, Sendai, Japan.

Department of Pediatrics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.

出版信息

Br J Haematol. 2022 Mar;196(5):1257-1261. doi: 10.1111/bjh.17988. Epub 2021 Dec 8.

DOI:10.1111/bjh.17988

PMID:34879431

Abstract

In this study, we performed a retrospective analysis of a cohort of Japanese paediatric patients with B-cell precursor (BCP)-acute lymphoblastic leukaemia (ALL) treated with a Berlin-Frankfurt-Münster (BFM)95-based protocol, to clarify the incidence, clinical characteristics, and risk factors of osteonecrosis (ON) in comparison to the ALL-02 protocol. We identified a high frequency of ON with the BFM95-based protocol compared to the ALL-02 protocol. The incidence of symptomatic ON with the BFM95-based protocol is comparable to previous studies in Western countries. We believe that the type of treatment regimen has more impact on the incidence of symptomatic ON in paediatric ALL than ethnicity.

摘要

在这项研究中，我们对接受柏林-法兰克福-慕尼黑（BFM）95 方案治疗的日本儿童 B 细胞前体（BCP）-急性淋巴细胞白血病（ALL）患者队列进行了回顾性分析，以明确与 ALL-02 方案相比，骨坏死（ON）的发生率、临床特征和危险因素。与 ALL-02 方案相比，我们发现 BFM95 方案的 ON 发生率较高。BFM95 方案引起的有症状 ON 的发生率与西方国家的既往研究相当。我们认为，治疗方案的类型对儿童 ALL 中症状性 ON 的发生率的影响大于种族。