Klamerus K J, Munger M A
Am J Hosp Pharm. 1986 Jun;43(6):1479-82.
Eleven institutions that participated in the Coronary Artery Surgery Study (CASS) were surveyed to obtain information about the types of cardioplegic solutions used at these institutions. A short-answer questionnaire designed to obtain specific information about the composition and method of preparation of cardioplegic solutions was sent to each institution. Institutions that did not reply within four weeks were sent a second questionnaire. Nine institutions returned completed questionnaires. Four institutions used several different cardioplegic solutions, resulting in a total of 14 evaluable solutions. Six hospitals used a chemical-based cardioplegic solution, one used a blood-based solution, and two used a combination of blood and chemicals as a cardioplegic-solution base. Chloride and potassium were found in all 14 solutions, although the amounts varied widely. Dextrose was included in eight of the nine chemical-based solutions, and bicarbonate and sodium were each used in seven of the nine solutions. Centers using chemical-based cardioplegic solutions compounded them daily or froze them with a one-week expiration date; blood-based solutions had to be prepared daily. Although interinstitutional differences in dosage were evident, the cardioplegic solutions used in the institutions participating in the CASS had many similar components. Data on the composition of these solutions can be used as a guideline for developing a cardioplegic solution.
对参与冠状动脉手术研究（CASS）的11家机构进行了调查，以获取这些机构所使用的心脏停搏液类型的信息。向每个机构发送了一份简答题问卷，旨在获取有关心脏停搏液成分和制备方法的具体信息。未在四周内回复的机构会收到第二份问卷。9家机构返回了完整的问卷。4家机构使用了几种不同的心脏停搏液，总共得到14种可评估的溶液。6家医院使用基于化学的心脏停搏液，1家使用基于血液的溶液，2家使用血液和化学物质的组合作为心脏停搏液的基础。在所有14种溶液中都发现了氯和钾，尽管含量差异很大。9种基于化学的溶液中有8种含有葡萄糖，9种溶液中有7种分别使用了碳酸氢盐和钠。使用基于化学的心脏停搏液的中心每天配制溶液或将其冷冻，有效期为一周；基于血液的溶液必须每天制备。尽管机构间在剂量上存在明显差异，但参与CASS的机构所使用的心脏停搏液有许多相似的成分。这些溶液的成分数据可作为开发心脏停搏液的指导。
