Burks A W, Steele R W
Ann Allergy. 1986 Jul;57(1):3-13.
Selective IgA deficiency is the most common form of immunodeficiency. Certain select populations, including allergic individuals, patients with autoimmune and gastrointestinal tract disease and patients with recurrent upper respiratory tract illnesses, have an increased incidence of this disorder. These patients have the unique ability to form various antibodies and auto-antibodies including anti-IgA antibodies. Failure of terminal differentiation of the B lymphocyte is the primary defect in IgA deficiency. Treatment should be directed toward the underlying disease associated with this immune disorder. These patients should be advised of the consequences of improperly administered blood or blood products.
选择性IgA缺乏是最常见的免疫缺陷形式。某些特定人群，包括过敏个体、自身免疫性疾病和胃肠道疾病患者以及复发性上呼吸道疾病患者，这种疾病的发病率会增加。这些患者具有形成各种抗体和自身抗体（包括抗IgA抗体）的独特能力。B淋巴细胞终末分化失败是IgA缺乏的主要缺陷。治疗应针对与这种免疫紊乱相关的基础疾病。应告知这些患者不当输注血液或血液制品的后果。
