Horowitz S, Hong R
Birth Defects Orig Artic Ser. 1975;11(1):129-33.
The clinical spectrum of IgA deficiency varies from good health to respiratory, gastrointestinal, autoimmune and malignant disorders. Evaluation of B lymphocytes with surface IgA receptors in this disease reveals cap formation, decreased to normal density of IgA receptors, and IgA secretion following pokeweed stimulation. Further study of antigen-induced B-lymphocyte phenomena is needed. The presence of decreased numbers of T-cell markers in some individuals with IgA deficiency suggests a T-"helper" cell defect.
IgA缺乏症的临床谱范围广泛，从健康状态到呼吸、胃肠、自身免疫和恶性疾病不等。对患有该疾病的带有表面IgA受体的B淋巴细胞进行评估，结果显示有帽形成现象，IgA受体密度降至正常水平，以及在商陆刺激后有IgA分泌。还需要对抗原诱导的B淋巴细胞现象做进一步研究。一些IgA缺乏症患者体内T细胞标志物数量减少，这表明存在T“辅助”细胞缺陷。
