Toge T, Tomota S, Aratani K, Kameda A, Yamada H, Yanagawa E, Hattori T
Gan To Kagaku Ryoho. 1986 Apr;13(4 Pt 2):1258-63.
The enhancement of antitumor effects by combination of biological response modifiers (BRM) was investigated on the basis of their action mechanisms. Experimentally, significant inhibition of tumor growth by combination treatment with BRM, which eliminated immune suppressive mechanisms and in turn enhanced immune responses, was observed. Furthermore, inhibition of tumor growth was observed under conditions of uniform biorhythm in mice and the effect of modification of biorhythm was enhanced by combination with BRM. Clinically, combination treatment of plasma exchange and LAK-cell adoptive immunotherapy was discussed.
基于生物反应调节剂（BRM）的作用机制，对其联合使用增强抗肿瘤效果进行了研究。在实验中，观察到BRM联合治疗可显著抑制肿瘤生长，该联合治疗消除了免疫抑制机制，进而增强了免疫反应。此外，在小鼠生物节律一致的条件下也观察到了肿瘤生长的抑制，并且与BRM联合使用可增强生物节律改变的效果。在临床上，还讨论了血浆置换与LAK细胞过继性免疫治疗的联合治疗。
