Hanaue H, Kurosawa T, Miyakawa S, Kitano Y, Nemoto A, Yamoto H, Asagoe T, Shikata J
Gan To Kagaku Ryoho. 1986 Apr;13(4 Pt 2):1285-9.
The influence of a biological response modifier on thoracic lymphocytes was studied clinically and experimentally. The thoracic lymphocytes and peripheral blood were taken from nine cases of gastric cancer relapse before and after the administration of hemolytic streptococci, OK-432 (PIC), for immunological examination. T: B cell ratio, T cell ratio and ADCC activity of the thoracic lymphocytes and peripheral blood were not changed but the NK activities of both were increased. The juvenilization of lymphocytes was reduced but that of the peripheral blood was not changed. The number and the ratio of T cells in the thoracic lymphocytes of Wistar rats were considerably increased by the administration of PIC but they were reduced in the peripheral blood. T-cell subsets of thoracic lymphocytes and peripheral blood were hardly changed by the administration of PIC. In the case immunological treatment, the thoracic lymphocytes and blood lymphocytes should be monitored because their biological specificities are different.
临床上和实验上研究了一种生物反应调节剂对胸段淋巴细胞的影响。从9例胃癌复发患者在给予溶血链球菌OK-432（PIC）前后采集胸段淋巴细胞和外周血进行免疫学检查。胸段淋巴细胞和外周血的T：B细胞比值、T细胞比值和ADCC活性未改变，但两者的NK活性均增加。淋巴细胞的年轻化程度降低，但外周血的未改变。给予PIC后，Wistar大鼠胸段淋巴细胞中T细胞的数量和比例显著增加，但外周血中的则降低。给予PIC后，胸段淋巴细胞和外周血的T细胞亚群几乎未改变。在进行免疫治疗时，应监测胸段淋巴细胞和血液淋巴细胞，因为它们的生物学特性不同。
