手掌小鱼际微血管区面积作为高血压患者动脉僵硬度的敏感预测指标。

Opisthenar microvessel area as a sensitive predictive index of arterial stiffness in hypertensive patients.

机构信息

Yanbian University Hospital, Yanji City, Jilin Province, China.

Department of Physiology and Biomedical Sciences, Ischemic/Hypoxic Disease Institute, Seoul National University, College of Medicine, Seoul, Korea.

出版信息

Sci Rep. 2021 Dec 8;11(1):23616. doi: 10.1038/s41598-021-02294-z.

DOI:10.1038/s41598-021-02294-z

PMID:34880253

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8654907/

Abstract

We aimed to analyze whether opisthenar microvessel area (OMA, measured with Optical Coherence Tomography (OCT) angiography) was associated with blood pressure (BP), arterial stiffness and whether OMA can predict arterial stiffness in hypertensive (HTN) patients. Results from 90 participants showed that BP, brachial-ankle pulse wave velocity (baPWV) and ankle brachial index (ABI) were significantly higher but OMA (in control, with cold- and warm-stimulation, NT, CST, HST and the differences, CSD, HSD) were significantly reduced in HTN group (n = 36) compared to non-HTN (n = 54). NT, CST, HST and HSD showed negative correlations with baPWV and ABI in all participants, female (n = 47) and male group (n = 43), but the correlation was absent when the participants were divided into HTN and non-HTN. Logistic Regression analysis showed that only baPWV was a significant risk factor for HSD (OR 19.7, 95%CI 4.959-78.733, p < 0.0001) but not the age, BMI, smoking, drinking or exercise status (p > 0.05). Receiver Operating Characteristics analysis for HSD was 0.781, 0.804, 0.770, respectively. HSD < 9439.5 μm predicted high BP and arterial stiffness (95% CI in all participants: baPWV, 0.681-0.881, SBP, 0.709-0.900, DBP, 0.672-0.867, p < 0.001). These results suggest that OMA is a sensitive index to predict arterial stiffness in HTN population.

摘要

我们旨在分析尺动脉优势微血管区（OMA，采用光学相干断层扫描血管造影术测量）是否与血压（BP）、动脉僵硬度相关，以及 OMA 是否可以预测高血压（HTN）患者的动脉僵硬度。90 名参与者的结果显示，与非 HTN 组（n=54）相比，HTN 组（n=36）的 BP、肱踝脉搏波速度（baPWV）和踝臂指数（ABI）显著升高，而 OMA（在冷、热刺激、NT、CST、HST 和差值 CSD、HSD 时）显著降低。在所有参与者、女性（n=47）和男性组（n=43）中，NT、CST、HST 和 HSD 与 baPWV 和 ABI 呈负相关，但当参与者分为 HTN 和非 HTN 时，这种相关性不存在。Logistic 回归分析显示，只有 baPWV 是 HSD 的显著危险因素（OR 19.7，95%CI 4.959-78.733，p<0.0001），而年龄、BMI、吸烟、饮酒或运动状况不是（p>0.05）。HSD 的受试者工作特征分析分别为 0.781、0.804、0.770。HSD<9439.5 μm 预测高血压和动脉僵硬（所有参与者的 95%CI：baPWV，0.681-0.881，SBP，0.709-0.900，DBP，0.672-0.867，p<0.001）。这些结果表明，OMA 是预测 HTN 人群动脉僵硬度的敏感指标。