Ray Suman Kumar, Mukherjee Sukhes
Department of Applied Sciences, Indira Gandhi Technological and Medical Sciences University, Arunachal Pradesh, India.
Department of Biochemistry, All India Institute of Medical Sciences, Bhopal, Madhya Pradesh, India.
Avicenna J Med. 2021 Dec 2;11(4):210-216. doi: 10.1055/s-0041-1735383. eCollection 2021 Oct.
Mucormycosis (also known as black fungus) is caused by fungi of the Zygomycetes class and is the third most common invasive mycosis after candidiasis and aspergillosis. They colonize a large number of patients without invading them. Systemic glucocorticoids are currently used to treat severe Coronavirus disease 19 (COVID-19). In such patients, opportunistic fungal infections are a problem. Although COVID-19-related pulmonary aspergillosis is becoming more common, mucormycosis is still uncommon. Mucormycosis normally appears 10 to 14 days after being admitted to the hospital. Mucormycosis is a rare but dangerous infection that can make extreme COVID-19 worse. Mucormycosis is more likely to occur in people who have diabetes mellitus and other risk factors. Mucormycosis is most likely exacerbated by concurrent glucocorticoid treatment. To improve outcomes, a high index of suspicion and aggressive management is required. Excessive usage of steroids, monoclonal antibodies, and broad-spectrum antibiotics might cause the formation or worsen of a fungal infection. A high index of suspicion and aggressive management are needed. In patients with COVID-19 infection, physicians should be vigilant of the likelihood of subsequent invasive fungal infections. To enhance results in pulmonary mucormycosis, early diagnosis and treatment are critical. Confirmation of the clinical form necessitates a combination of symptoms that are consistent with tissue invasion histologically. Combining various clinical data and the isolation of the fungus from clinical samples in culture is needed for the probable diagnosis of mucormycosis. The organism that causes mucormycosis is identified using macroscopic and microscopic morphological criteria, carbohydrate assimilation, and the maximum temperature at which they can expand. Mucormycosis must be treated with antifungal medication prescribed by a doctor. It may necessitate surgery in some circumstances, and it can result in the loss of the upper jaw and, in some situations, an eye.
毛霉病(也称为黑真菌病)由接合菌纲真菌引起,是仅次于念珠菌病和曲霉病的第三常见侵袭性真菌病。它们定植于大量患者但不侵袭人体。全身性糖皮质激素目前用于治疗重症冠状病毒病19(COVID-19)。在这类患者中,机会性真菌感染是个问题。虽然COVID-19相关的肺曲霉病越来越常见,但毛霉病仍然不常见。毛霉病通常在入院后10至14天出现。毛霉病是一种罕见但危险的感染,会使重症COVID-19病情加重。毛霉病更易发生于患有糖尿病及其他风险因素的人群。同时使用糖皮质激素治疗很可能会加重病情。为改善治疗效果,则需要高度怀疑并积极处理。过度使用类固醇、单克隆抗体和广谱抗生素可能导致真菌感染的形成或加重。需要高度怀疑并积极处理。对于COVID-19感染患者,医生应警惕后续侵袭性真菌感染的可能性。为提高肺毛霉病的治疗效果,早期诊断和治疗至关重要。确诊临床类型需要一系列与组织侵袭在组织学上相符的症状。毛霉病的疑似诊断需要结合各种临床数据并从临床样本中培养分离出真菌。通过宏观和微观形态学标准、碳水化合物同化作用以及它们能够生长的最高温度来鉴定引起毛霉病的病原体。毛霉病必须用医生开的抗真菌药物治疗。在某些情况下可能需要手术,并且可能导致上颌骨缺失,在某些情况下还会导致失明。