Center for Reproductive Medicine, Cheeloo College of Medicine, Shandong University, Jinan, China.
The Key Laboratory of Reproductive Endocrinology of Ministry of Education, National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Jinan, China.
BJOG. 2022 Jun;129(7):1030-1038. doi: 10.1111/1471-0528.17045. Epub 2021 Dec 29.
To evaluate the effect of dehydroepiandrosterone (DHEA) pre-treatment before in vitro fertilization and embryo transfer (IVF-ET) on the live birth rate in infertile women with poor ovarian response (POR) defined according to the Bologna criteria.
A randomized, double-blind, placebo-controlled trial.
Nine reproductive medical centers in China.
A total of 821 participants with POR defined according to the Bologna criteria were enrolled in the study between April 2016 and December 2018.
Eligible participants were randomly assigned to receive either DHEA (n = 410) or placebo (n = 411) treatments for 4-12 weeks prior to IVF-ET, in a 1:1 ratio.
Live birth rate after the first embryo transfer.
Thirty-six (8.8%) of 410 women in the DHEA group and 37 (9.0%) of 411 women in the placebo group had a live birth, with no significant difference observed between groups (relative risk, 0.98, 95% CI, 0.63-1.51; p = 0.911). There were no significant differences in the number of retrieved oocytes, and the rates of clinical pregnancy, pregnancy loss, and cumulative live births between the two groups.
DHEA administration prior to IVF-ET had no beneficial effect on the live birth rate relative to placebo in women with POR defined according to the Bologna criteria.
No benefit was found in poor ovarian responders who received DHEA administration prior to IVF.
评估脱氢表雄酮（DHEA）预处理对根据博洛尼亚标准定义的卵巢反应不良（POR）不孕妇女体外受精和胚胎移植（IVF-ET）活产率的影响。
随机、双盲、安慰剂对照试验。
中国 9 个生殖医学中心。
共有 821 名根据博洛尼亚标准定义为 POR 的参与者纳入本研究，研究时间为 2016 年 4 月至 2018 年 12 月。
合格的参与者被随机分配接受 DHEA（n=410）或安慰剂（n=411）治疗，在 IVF-ET 前 4-12 周，以 1:1 的比例。
首次胚胎移植后的活产率。
DHEA 组 410 名女性中有 36 名（8.8%）和安慰剂组 411 名女性中有 37 名（9.0%）活产，两组间无显著差异（相对风险，0.98；95%CI，0.63-1.51；p=0.911）。两组间获卵数、临床妊娠率、妊娠丢失率和累积活产率无显著差异。
根据博洛尼亚标准定义的 POR 妇女在 IVF-ET 前给予 DHEA 治疗与安慰剂相比，活产率无获益。
在接受 IVF 的卵巢反应不良患者中，给予 DHEA 并没有带来益处。
