Salazar-Lindo E, Sack R B, Chea-Woo E, Kay B A, Piscoya Z A, Leon-Barua R, Yi A
J Pediatr. 1986 Aug;109(2):355-60. doi: 10.1016/s0022-3476(86)80404-8.
To evaluate the efficacy of early treatment with erythromycin on the duration of fecal excretion and of diarrhea associated with Campylobacter jejuni, 170 patients, age 3 to 60 months, were randomly assigned in a double-blind fashion to receive either erythromycin ethyl succinate or placebo immediately after being seen at Cayetano Heredia Hospital because of acute dysentery. The groups' pretreatment characteristics were comparable. Of the 30 patients with stools positive for C. jejuni, 12 were in the placebo group and 16 in the treatment group. After 2 days of treatment, none of the patients in the placebo group and 36% of those in the erythromycin group had normal stools (P less than 0.05). After 5 days of treatment, 50% of the patients in the placebo group and 93% of those in the erythromycin group had normal stools (P less than 0.02). Fecal excretion of the organism continued significantly longer in the placebo group (P less than 0.01). There were no treatment failures in the treatment group compared with five (42%) in the placebo group (P less than 0.01). Thus, early administration of erythromycin significantly reduced the duration of both diarrhea and fecal excretion of the organism in infants and children with acute dysentery associated with C. jejuni.
为评估早期使用红霉素治疗对空肠弯曲菌所致粪便排泄持续时间及腹泻的疗效，170名年龄在3至60个月的患者因急性痢疾在卡耶塔诺·埃雷迪亚医院就诊后，被随机双盲分组，分别接受琥乙红霉素或安慰剂治疗。两组的治疗前特征具有可比性。在30名空肠弯曲菌粪便检测呈阳性的患者中，12名在安慰剂组，16名在治疗组。治疗2天后，安慰剂组无一例患者粪便恢复正常，而红霉素组有36%的患者粪便恢复正常（P<0.05）。治疗5天后，安慰剂组50%的患者粪便恢复正常，红霉素组93%的患者粪便恢复正常（P<0.02）。安慰剂组中该菌的粪便排泄持续时间显著更长（P<0.01）。治疗组无治疗失败病例，而安慰剂组有5例（42%）治疗失败（P<0.01）。因此，早期给予红霉素可显著缩短与空肠弯曲菌相关的急性痢疾婴幼儿的腹泻持续时间及该菌的粪便排泄时间。
