Jerzy Haber Institute of Catalysis and Surface Chemistry, Polish Academy of Sciences, 30-239 Krakow, Poland.
Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, 30-387 Krakow, Poland.
Int J Mol Sci. 2021 Nov 25;22(23):12762. doi: 10.3390/ijms222312762.
Cancer is one of the most important health problems of our population, and one of the common anticancer treatments is chemotherapy. The disadvantages of chemotherapy are related to the drug's toxic effects, which act on cancer cells and the healthy part of the body. The solution of the problem is drug encapsulation and drug targeting. The present study aimed to develop a novel method of preparing multifunctional 5-Fluorouracil (5-FU) nanocarriers and their in vitro characterization. 5-FU polyaminoacid-based core@shell nanocarriers were formed by encapsulation drug-loaded nanocores with polyaminoacids multilayer shell via layer-by-layer method. The size of prepared nanocarriers ranged between 80-200 nm. Biocompatibility of our nanocarriers as well as activity of the encapsulated drug were confirmed by MTT tests. Moreover, the ability to the real-time observation of developed nanocarriers and drug accumulation inside the target was confirmed by fluorine magnetic resonance imaging (F-MRI).
癌症是当前人类最重要的健康问题之一，化疗是常见的癌症治疗手段之一。化疗的缺点与药物的毒性作用有关，这些毒性作用不仅作用于癌细胞，也会作用于健康的身体组织。药物包裹和靶向投递是解决这一问题的方法。本研究旨在开发一种新的多功能 5-氟尿嘧啶（5-FU）纳米载体的制备方法，并对其进行体外特性分析。通过层层自组装的方法，用聚氨基酸多层壳包裹载药纳米核，形成 5-FU 聚氨基酸核壳纳米载体。所制备的纳米载体的粒径在 80-200nm 之间。通过 MTT 实验，验证了我们的纳米载体的生物相容性和包封药物的活性。此外，通过氟磁共振成像（F-MRI），我们还证实了开发的纳米载体实时观察和药物在靶内积累的能力。
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