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负载聚乙烯醇/5-氟尿嘧啶/锌铝层状双氢氧化物的双功能氧化铁纳米颗粒用于同步药物和靶向递送系统

Dual-Functional Iron Oxide Nanoparticles Coated with Polyvinyl Alcohol/5-Fluorouracil/Zinc-Aluminium-Layered Double Hydroxide for a Simultaneous Drug and Target Delivery System.

作者信息

Ebadi Mona, Bullo Saifullah, Buskaran Kalaivani, Hussein Mohd Zobir, Fakurazi Sharida, Pastorin Giorgia

机构信息

Materials Synthesis and Characterization Laboratory, Institute of Advanced Technology (ITMA), Universiti Putra Malaysia, Serdang 43400, Malaysia.

Department of Management Sciences and Technology, Begum Nusrat Bhutto Women, University Sukkur, Sindh 65200, Pakistan.

出版信息

Polymers (Basel). 2021 Mar 10;13(6):855. doi: 10.3390/polym13060855.

DOI:10.3390/polym13060855
PMID:33802205
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8001192/
Abstract

Iron oxide nanoparticles are suitable for biomedical applications owing to their ability to anchor to various active agents and drugs, unique magnetic properties, nontoxicity, and biocompatibility. In this work, the physico-chemical and magnetic properties, as well as the cytotoxicity, of FeO nanoparticles coated with a polymeric carrier and loaded with a 5-fluorouracil (5-FU) anti-cancer drug are discussed. The synthesized FeO nanoparticles were coated with polyvinyl alcohol and Zn/Al-layered double hydroxide as the drug host. The XRD, DTA/TG, and FTIR analyzes confirmed the presence of the coating layer on the surface of nanoparticles. The results showed a decrease in saturation magnetization of bare FeO nanoparticles after coating with the PVA/5FU/Zn/Al-LDH layer. In addition, the presence of the coating prevented the agglomeration of nanoparticles. Furthermore, the pseudo-second-order equation governed the kinetics of drug release. Finally, the coated nanoparticles showed stronger activity against liver cancer cells (HepG2) compared to that of the naked 5-FU drug, and displayed no cytotoxicity towards 3T3 fibroblast cell lines. The results of the present study demonstrate the potential of a nano delivery system for cancer treatment.

摘要

由于氧化铁纳米颗粒能够附着各种活性剂和药物，具有独特的磁性、无毒且具有生物相容性，因此适用于生物医学应用。在这项工作中，讨论了涂覆有聚合物载体并负载5-氟尿嘧啶（5-FU）抗癌药物的FeO纳米颗粒的物理化学性质、磁性以及细胞毒性。合成的FeO纳米颗粒涂覆有聚乙烯醇和Zn/Al层状双氢氧化物作为药物载体。XRD、DTA/TG和FTIR分析证实了纳米颗粒表面存在涂层。结果表明，用PVA/5FU/Zn/Al-LDH层涂覆后，裸FeO纳米颗粒的饱和磁化强度降低。此外，涂层的存在防止了纳米颗粒的团聚。此外，伪二级方程控制药物释放动力学。最后，与裸5-FU药物相比，涂覆的纳米颗粒对肝癌细胞（HepG2）表现出更强的活性，并且对3T3成纤维细胞系没有细胞毒性。本研究结果证明了纳米递送系统在癌症治疗中的潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2902/8001192/47a97a57aa1c/polymers-13-00855-g012.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2902/8001192/b5c7cfc298cc/polymers-13-00855-g005a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2902/8001192/e5fa856e547a/polymers-13-00855-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2902/8001192/9cc577ecffc5/polymers-13-00855-g007.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2902/8001192/4705915ca016/polymers-13-00855-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2902/8001192/efc6cef3088d/polymers-13-00855-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2902/8001192/128cefe5bcbd/polymers-13-00855-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2902/8001192/47a97a57aa1c/polymers-13-00855-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2902/8001192/880b7b3cf2dc/polymers-13-00855-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2902/8001192/29ca63e0e3ce/polymers-13-00855-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2902/8001192/71afad349cc7/polymers-13-00855-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2902/8001192/4498ad833d52/polymers-13-00855-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2902/8001192/b5c7cfc298cc/polymers-13-00855-g005a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2902/8001192/e5fa856e547a/polymers-13-00855-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2902/8001192/9cc577ecffc5/polymers-13-00855-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2902/8001192/4d878c5614e0/polymers-13-00855-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2902/8001192/4705915ca016/polymers-13-00855-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2902/8001192/efc6cef3088d/polymers-13-00855-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2902/8001192/128cefe5bcbd/polymers-13-00855-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2902/8001192/47a97a57aa1c/polymers-13-00855-g012.jpg

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