School of Medical Sciences, University of Campinas, Campinas 13083894, Brazil.
Center of Molecular Biology and Pharmacogenetics, Scientific and Technological Bioresource Nucleus, Universidad de La Frontera, Temuco 4811230, Chile.
Int J Mol Sci. 2021 Nov 25;22(23):12765. doi: 10.3390/ijms222312765.
The purpose of this systematic review was to map out and summarize scientific evidence on dysregulated microRNAs (miRNAs) that can be possible biomarkers or therapeutic targets for cisplatin nephrotoxicity and have already been tested in humans, animals, or cells. In addition, an in silico analysis of the two miRNAs found to be dysregulated in the majority of studies was performed. A literature search was performed using eight databases for studies published up to 4 July 2021. Two independent reviewers selected the studies and extracted the data; disagreements were resolved by a third and fourth reviewers. A total of 1002 records were identified, of which 30 met the eligibility criteria. All studies were published in English and reported between 2010 and 2021. The main findings were as follows: (a) miR-34a and miR-21 were the main miRNAs identified by the studies as possible biomarkers and therapeutic targets of cisplatin nephrotoxicity; (b) the in silico analysis revealed 124 and 131 different strongly validated targets for miR-34a and miR-21, respectively; and (c) studies in humans remain scarce.
本系统评价的目的是绘制和总结在人类、动物或细胞中已经过测试的，与顺铂肾毒性相关的失调 microRNAs（miRNAs）的科学证据，这些 miRNAs 可能成为生物标志物或治疗靶点。此外，还对大多数研究中发现失调的两种 miRNA 进行了计算机分析。使用 8 个数据库对截至 2021 年 7 月 4 日发表的研究进行了文献检索。两名独立评审员选择了研究并提取了数据；分歧由第三和第四名评审员解决。共确定了 1002 条记录，其中 30 条符合入选标准。所有研究均以英文发表，报告时间为 2010 年至 2021 年。主要发现如下：（a）miR-34a 和 miR-21 是研究中确定的与顺铂肾毒性相关的生物标志物和治疗靶点的主要 miRNA；（b）计算机分析分别揭示了 miR-34a 和 miR-21 的 124 个和 131 个不同的强验证靶标；（c）针对人类的研究仍然很少。
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