连续流合成丙泊酚。
Continuous Flow Synthesis of Propofol.
机构信息
CNRS, INSA Rouen, UNIROUEN, Normandie University, COBRA, 76000 Rouen, France.
Institut Universitaire de France, 1 Rue Descartes, 75231 Paris, France.
出版信息
Molecules. 2021 Nov 26;26(23):7183. doi: 10.3390/molecules26237183.
Abstract
Herein, we report a continuous flow process for the synthesis of 2,6-diisopropylphenol-also known as Propofol-a short-acting intravenous anesthesia, widely used in intensive care medicine to provide sedation and hypnosis. The synthesis is based on a two-step procedure: a double Friedel-Crafts alkylation followed by a decarboxylation step, both under continuous flow.
摘要
在此，我们报告了一种连续流工艺，用于合成 2,6-二异丙基苯酚-也称为异丙酚-一种短效静脉麻醉剂，广泛用于重症医学中提供镇静和催眠。该合成基于两步法：双 Friedel-Crafts 烷基化反应，随后是连续流条件下的脱羧反应。
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