Lummiss Justin A M, Morse Peter D, Beingessner Rachel L, Jamison Timothy F
Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA, 02139, USA.
Chem Rec. 2017 Jul;17(7):667-680. doi: 10.1002/tcr.201600139. Epub 2017 Feb 28.
Technological advances have an important role in the design of greener synthetic processes. In this Personal Account, we describe a wide range of thermal, photochemical, catalytic, and biphasic chemical transformations examined by our group. Each of these demonstrate how the merits of a continuous flow synthesis platform can align with some of the goals put forth by the Twelve Principles of Green Chemistry. In particular, we illustrate the potential for improved reaction efficiency in terms of atom economy, product yield and reaction rates, the ability to design synthetic process with chemical and solvent waste reduction in mind as well as highlight the benefits of the real-time monitoring capabilities in flow for highly controlled synthetic output.
技术进步在更绿色合成工艺的设计中起着重要作用。在这篇个人述评中，我们描述了我们团队研究的广泛的热、光化学、催化和双相化学转化。这些研究均展示了连续流合成平台的优点如何与绿色化学十二原则提出的一些目标相一致。特别是，我们阐述了在原子经济性、产物收率和反应速率方面提高反应效率的潜力，设计合成工艺时考虑减少化学和溶剂废弃物的能力，以及强调流动过程中实时监测功能对于高度可控合成输出的益处。
