Department of Prevention Medicine, Hangzhou Normal University, Hangzhou 311121, China.
Int J Environ Res Public Health. 2021 Nov 23;18(23):12311. doi: 10.3390/ijerph182312311.
Early screening and detection of individuals at high risk of high-frequency hearing loss and identification of risk factors are critical to reduce the prevalence at community level. However, unlike those for individuals facing occupational auditory hazards, a limited number of hearing loss screening models have been developed for community residents. Therefore, this study used lasso regression with 10-fold cross-validation for feature selection and model construction on 38 questionnaire-based variables of 4010 subjects and applied the model to training and testing cohorts to obtain a risk score. The model achieved an area under the curve (AUC) of 0.844 in the model validation stage and individuals' risk scores were subsequently stratified into low-, medium-, and high-risk categories. A total of 92.79% (1094/1179) of subjects in the high-risk category were confirmed to have hearing loss by audiometry test, which was 3.7 times higher than that in the low-risk group (25.18%, 457/1815). Half of the key indicators were related to modifiable contexts, and they were identified as significantly associated with the incident hearing loss. These results demonstrated that the developed model would be feasible to identify residents at high risk of hearing loss via regular community-level health examinations and detecting individualized risk factors, and eventually provide precision interventions.
早期筛选和检测高频听力损失高危个体,并识别危险因素对于降低社区水平的患病率至关重要。然而,与面临职业性听觉危害的个体不同,针对社区居民的听力损失筛查模型数量有限。因此,本研究使用 10 折交叉验证的套索回归进行特征选择和模型构建,对 4010 名受试者的 38 个基于问卷的变量进行分析,并将模型应用于训练和测试队列,以获得风险评分。在模型验证阶段,该模型的曲线下面积(AUC)为 0.844,随后将个体的风险评分分层为低、中、高风险类别。在高危组的 1179 名受试者中,有 92.79%(1094/1179)通过听力测试被确诊为听力损失,这一比例是低危组(25.18%,457/1815)的 3.7 倍。一半的关键指标与可改变的环境有关,并且与听力损失的发生显著相关。这些结果表明,该模型可以通过定期的社区水平健康检查识别听力损失高危居民,并检测个体的危险因素,最终提供精准的干预措施。
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