Cromwell L D, Freeny P C, Kerber C W, Kunz L L, Harris A B, Shaw C M
AJR Am J Roentgenol. 1986 Sep;147(3):627-31. doi: 10.2214/ajr.147.3.627.
A toxicologic-pathologic study of isobutyl-2-cyanoacrylate (Bucrylate) was carried out first in dogs and then in humans whose arteriovenous malformations were infused with this embolic agent. The canine specimens obtained at 7, 18, 28, and 147 days after embolization showed the development of a mild histiocytic giant cell reaction, which evolved to end-state sclerotic arteritis. The response was confined to the vessels and did not involve contiguous parenchymal tissues. Ten human specimens, obtained from 1 hr to 7 years after treatment, showed a similar bland reaction with no evidence of suppuration or premalignant changes.
首先在犬类身上进行了异丁基-2-氰基丙烯酸酯（布丙烯酸酯）的毒理学病理研究，然后在患有动静脉畸形并注入这种栓塞剂的人类身上进行了研究。栓塞后7天、18天、28天和147天获取的犬类标本显示出现了轻度组织细胞性巨细胞反应，该反应演变为终末期硬化性动脉炎。这种反应局限于血管，未累及相邻的实质组织。治疗后1小时至7年获取的10份人类标本显示出类似的温和反应，没有化脓或癌前病变的迹象。
