心肌炎与新冠病毒mRNA疫苗：一种涉及双链RNA的机制假说
Myocarditis and COVID-19 mRNA vaccines: a mechanistic hypothesis involving dsRNA.
作者信息
Milano Gerard, Gal Jocelyn, Creisson Anne, Chamorey Emmanuel
机构信息
Centre Antoine Lacassagne, Unité Propre de Recherche 7497, Université Côte d'Azur, 06100, Nice, France.
Centre Antoine Lacassagne, UNS EA 7497 Nice University, 33 Avenue de Valombrose, 06189, Nice, France.
出版信息
Future Virol. 2021 Nov. doi: 10.2217/fvl-2021-0280. Epub 2021 Dec 6.
While tolerance to COVID-19 vaccination is considered satisfactory, a phenomenon of myocarditis, although rare, is becoming a safety concern in mRNA COVID-19 vaccination. The presence of low residual levels of double-strand RNA (dsRNA) has been reported in mRNA COVID-19 vaccine preparations. dsRNA is a known inducer of immune-inflammatory reactions. dsRNA present in vaccine nanoparticles may be suspected to be at the origin of the still unexplained cases of myocarditis.
虽然人们认为对新冠病毒疫苗的耐受性令人满意，但心肌炎现象，尽管罕见，却正成为新冠病毒mRNA疫苗接种中的一个安全问题。据报道，在新冠病毒mRNA疫苗制剂中存在低残留水平的双链RNA（dsRNA）。dsRNA是一种已知的免疫炎症反应诱导剂。疫苗纳米颗粒中存在的dsRNA可能被怀疑是心肌炎病例仍无法解释的根源。
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