Department of Energy and Environmental Biotechnology, National Institute of Genetic Engineering and Biotechnology (NIGEB), 14965/161, Tehran, Iran; Department of Biotechnology, College of Science, University of Tehran, Tehran, Iran.
Immunology Research Center, Iran University of Medical Sciences, Tehran, Iran; Immunology Department, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Int Immunopharmacol. 2023 Apr;117:109934. doi: 10.1016/j.intimp.2023.109934. Epub 2023 Feb 27.
The worldwide spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has urged scientists to present some novel vaccine platforms during this pandemic to provide a rather prolonged immunity against this respiratory viral infection. In spite of many campaigns formed against the administration of mRNA-based vaccines, those platforms were the most novel types, which helped us meet the global demand by developing protection against COVID-19 and reducing the development of severe forms of this respiratory viral infection. Some societies are worry about the COVID-19 mRNA vaccine administration and the potential risk of genetic integration of inoculated mRNA into the human genome. Although the efficacy and long-term safety of mRNA vaccines have not yet been fully clarified, obviously their application has switched the mortality and morbidity of the COVID-19 pandemic. This study describes the structural features and technologies used in producing of COVID-19 mRNA-based vaccines as the most influential factor in controlling this pandemic and a successful pattern for planning to produce other kind of genetic vaccines against infections or cancers.
严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）在全球范围内的传播促使科学家在大流行期间提出了一些新的疫苗平台，以提供针对这种呼吸道病毒感染的持久免疫力。尽管针对 mRNA 疫苗接种的活动很多，但这些平台是最新型的平台，通过开发针对 COVID-19 的保护并减少这种呼吸道病毒感染的严重形式的发展，帮助我们满足了全球需求。一些社会担心 COVID-19 mRNA 疫苗接种和接种的 mRNA 潜在遗传整合入人类基因组的风险。尽管 mRNA 疫苗的疗效和长期安全性尚未完全阐明，但显然其应用改变了 COVID-19 大流行的死亡率和发病率。本研究描述了用于生产 COVID-19 mRNA 疫苗的结构特征和技术，这是控制这种大流行的最具影响力的因素，也是针对感染或癌症规划生产其他类型基因疫苗的成功模式。
