Department of Chemistry, University of Victoria, 3800 Finnerty Rd., Victoria, BC V8P 5C2, Canada.
Centre for Advanced Materials and Related Technology (CAMTEC), University of Victoria, 3800 Finnerty Rd., Victoria, BC V8W 2Y2, Canada.
Angew Chem Int Ed Engl. 2022 Jan 21;61(4):e202113235. doi: 10.1002/anie.202113235. Epub 2021 Dec 9.
We report on the synthesis of bivalent water-soluble calix[4]arene and calix[5]arene hosts, Super-sCx4 and Super-sCx5 as new broad-spectrum supramolecular binders of neuromuscular blocking agents (NMBAs). Synthesis was achieved using the target bisquaternary amine NMBAs as a template to link two highly anionic p-sulfonatocalixarene building blocks in aqueous solution. Bivalent anionic hosts Super-sCx4 and Super-sCx5 bind by engaging both quaternary amines present on a variety of NMBAs. We report low μM binding to structurally diverse alkyl, steroidal, curarine and benzylisoquinoline NMBAs with high selectivity over the neurotransmitter acetylcholine and a variety of other hydrophobic amines.
我们报告了二价水溶性杯[4]芳烃和杯[5]芳烃主体 Super-sCx4 和 Super-sCx5 的合成，它们是新的神经肌肉阻滞剂（NMBAs）的广谱超分子结合物。合成是使用目标双季铵盐 NMBAs 作为模板，在水溶液中连接两个高度阴离子对磺基杯芳烃建筑块来实现的。二价阴离子主体 Super-sCx4 和 Super-sCx5 通过与各种 NMBAs 上存在的两个季铵盐结合来进行结合。我们报告了对结构多样的烷基、甾体、筒箭毒碱和苯并异喹啉 NMBAs 的低 μM 结合，对神经递质乙酰胆碱和各种其他疏水性胺具有高选择性。
