Süleyman Demirel University Faculty of Medicine, Department of Medical Microbiology, Isparta, Turkey
Süleyman Demirel University Faculty of Medicine, Department of Psychiatry, Isparta, Turkey
Turkiye Parazitol Derg. 2021 Dec 2;45(4):241-246. doi: 10.4274/tpd.galenos.2021.68077.
Studies have implicated in the etiology of mental disorders because of its neurotropic nature and its ability to modulate neurotransmitter pathways. This study aims to investigate seroprevalence in patients with bipolar disorder and in healthy controls living in the Isparta Region of Turkey and to assess the probable relationship between and bipolar disorder.
Fourty-eight patients with bipolar disorder and 50 healthy controls were included in the study. Sociodemographic data, possible risk factors for infection and clinical characteristics were analyzed. Serum anti- IgM and IgG antibody levels were measured by using chemiluminescence immunoassay method (Roche Cobas e601 analyzer, Roche Diagnostics, Mannheim, Germany).
Anti- IgG seropositivity rates were determined as 18.8% and 20% in the patient group and the control group, respectively. No statistically significant relationship was observed between IgG seropositivity and bipolar disorder (p=0.876). In the study population, advanced age, low education level, living in a rural region and consumption of unwashed raw vegetable or fruit were found to be the significant risk factors for infection (p<0.05).
Our preliminary findings do not support the hypothesis that infection is related to bipolar disorder. However, further studies would require larger sample sizes to confirm our results.
由于其神经趋化性和调节神经递质途径的能力，研究表明 与精神障碍的病因有关。本研究旨在调查土耳其伊斯帕尔塔地区的双相情感障碍患者和健康对照者中的 血清流行率，并评估 与双相情感障碍之间的可能关系。
本研究纳入了 48 名双相情感障碍患者和 50 名健康对照者。分析了社会人口统计学数据、 感染的可能危险因素和临床特征。使用化学发光免疫分析法（罗氏 cobas e601 分析仪，罗氏诊断公司，曼海姆，德国）测量血清抗- IgM 和 IgG 抗体水平。
患者组和对照组的抗- IgG 血清阳性率分别为 18.8%和 20%。 IgG 血清阳性与双相情感障碍之间未观察到统计学显著关系（p=0.876）。在研究人群中，年龄较大、受教育程度较低、居住在农村地区以及食用未经清洗的生蔬菜或水果被认为是 感染的显著危险因素（p<0.05）。
我们的初步发现不支持 感染与双相情感障碍有关的假设。然而，需要更大的样本量来进一步研究以证实我们的结果。
