College of Integrated Traditional Chinese and Western Medicine, Gansu University of Traditional Chinese Medicine, Gansu, China.
Department of Emergency, Gansu Hospital of Traditional Chinese Medicine, Gansu, China.
Medicine (Baltimore). 2021 Dec 10;100(49):e28186. doi: 10.1097/MD.0000000000028186.
The purpose of this study is to determine the efficacy and safety of Cyclosporine A (CsA) for patients with steroid-resistant nephrotic syndrome (SRNS).
This study will be designed following the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols statement guidelines. Studies are identified through systematic searches in November 2021 with no restrictions on date and time, and publication status using the following bibliographic databases: Embase, Medline, PubMed, Web of Science, Science Direct, and the Cochrane Library. The risk of bias of included studies is estimated by taking into consideration the characteristics including random sequence generation, allocation concealment, blinding of patients, blinding of outcome assessment, completeness of outcome data, selective reporting, and other bias by Cochrane Collaboration's tool. Data synthesis and analyses are performed using Stata version 10.0 software.
The results of this systematic review and meta-analysis will be published in a peer-reviewed journal.
CsA may be an effective and safe therapy for SRNS. However, additional randomized controlled studies are needed to thoroughly assess the role of CsA in the treatment of SRNS.
10.17605/OSF.IO/P6YB9.
本研究旨在确定环孢素 A（CsA）治疗激素抵抗性肾病综合征（SRNS）患者的疗效和安全性。
本研究将遵循系统评价和荟萃分析方案首选报告项目的指南进行设计。研究通过系统搜索于 2021 年 11 月进行，对日期和时间以及出版物状态没有限制，使用以下书目数据库进行搜索：Embase、Medline、PubMed、Web of Science、Science Direct 和 Cochrane 图书馆。通过考虑包括随机序列生成、分配隐匿、患者盲法、结局评估盲法、结局数据完整性、选择性报告和 Cochrane 协作工具中的其他偏倚特征，评估纳入研究的偏倚风险。使用 Stata 版本 10.0 软件进行数据综合和分析。
本系统评价和荟萃分析的结果将发表在同行评议的期刊上。
CsA 可能是治疗 SRNS 的一种有效且安全的疗法。然而，需要更多的随机对照研究来彻底评估 CsA 在治疗 SRNS 中的作用。
10.17605/OSF.IO/P6YB9。
