Department of Orthopaedics, University of British Columbia.
Department of Orthopaedic Surgery, BC Children's Hospital.
J Pediatr Orthop. 2022 Jan 1;42(1):e59-e64. doi: 10.1097/BPO.0000000000001979.
Avascular necrosis (AVN) of the femoral head is a concerning complication that can result from treatments for developmental dysplasia of the hip (DDH). AVN can lead to degenerative osteoarthritis, persistent acetabular dysplasia, reduced function, and continuing hip pain. The incidence of AVN reported in the DDH literature is widely varied (0% to 73%). This variability may arise from lack of consensus on what constitutes true AVN in this patient population, and lack of clear criteria provided in studies reporting incidence rates.
A multicentre, prospective database of infants diagnosed with DDH between 2010 and 2014 from 0 to 18 months of age was analyzed for patients treated by closed reduction (CR). Twelve pediatric orthopaedic surgeons completed 2 rounds of AVN assessments. Deidentified anteroposterior radiographs at most recent follow-up were provided to surgeons along with patient age at radiographic assessment, length of follow-up, ands affected hip. Ten of 12 surgeons completed a third round of assessments where they were provided with 1 to 2 additional radiographs within the follow-up period. Radiographic criteria for total AVN described by Salter and colleagues were used. Surgeons rated the presence of AVN as "yes" or "no" and kappa values were calculated within and between rounds.
A total of 69 hips in 60 patients were assessed for AVN a median of 22 months (range: 12 to 36) post-CR. Interobserver kappa values for rounds 1, 2, and 3 were 0.52 (range: 0.11 to 0.90), 0.61 (range: 0.21 to 0.90), and 0.53 (range: 0.10 to 0.79), respectively. Intraobserver agreement for AVN diagnosis was an average of 0.72 (range: 0.31 to 0.96).
Despite using the most commonly referenced diagnostic criteria, radiographic diagnosis of AVN following CR in DDH patients demonstrated only moderate agreement across surgeons. The addition of sequential radiographs did not improve cross-observer reliability, and while substantial agreement was seen within observers, the range of intraobserver kappa values was large.
Level I-diagnostic study.
股骨头缺血性坏死(AVN)是髋关节发育不良(DDH)治疗后可能出现的一种令人担忧的并发症。AVN 可导致退行性骨关节炎、持续性髋臼发育不良、功能下降和持续的髋关节疼痛。DDH 文献中报告的 AVN 发生率差异很大(0%至 73%)。这种差异可能源于对该患者人群中真正的 AVN 缺乏共识,以及在报告发生率的研究中缺乏明确的标准。
对 2010 年至 2014 年间 0 至 18 个月龄诊断为 DDH 的婴儿进行多中心前瞻性数据库分析,对接受闭合复位(CR)治疗的患者进行分析。12 名小儿矫形外科医生完成了两轮 AVN 评估。将患者的年龄、影像学评估时的年龄、随访时间以及受影响的髋关节等信息与最近随访时的前后位 X 线片一起提供给医生。12 名外科医生中的 10 名完成了第三轮评估,其中在随访期间提供了 1 至 2 张额外的 X 线片。使用 Salter 同事描述的 AVN 总分类标准进行评估。外科医生将 AVN 的存在评为“是”或“否”,并计算了两轮和三轮之间的 Kappa 值。
60 名患者的 69 个髋关节在 CR 后中位数为 22 个月(范围:12 至 36)时接受了 AVN 评估。第 1、2 和 3 轮的观察者间 Kappa 值分别为 0.52(范围:0.11 至 0.90)、0.61(范围:0.21 至 0.90)和 0.53(范围:0.10 至 0.79)。AVN 诊断的观察者内一致性平均为 0.72(范围:0.31 至 0.96)。
尽管使用了最常参考的诊断标准,但 DDH 患者 CR 后 AVN 的放射学诊断结果仅在外科医生之间存在中等程度的一致性。添加连续 X 线片并没有提高跨观察者的可靠性,虽然观察者内有很大的一致性,但观察者内 Kappa 值的范围很大。
I 级诊断研究。