Department of Ophthalmology, Shiga University of Medical Science, Otsu, Japan.
Department of Pediatrics, Shiga University of Medical Science, Otsu, Japan.
PLoS One. 2021 Dec 10;16(12):e0261095. doi: 10.1371/journal.pone.0261095. eCollection 2021.
To evaluate the short-term effect on body weight (BW) gain after intravitreal bevacizumab (IVB) for retinopathy of prematurity (ROP).
This was a retrospective 1:1 matched case-control study. Infants with ROP treated by IVB or photocoagulation (PC) at Shiga University of Medical Science Hospital between April 2010 and December 2019 were included in the study. To match BWs at treatment between the IVB and PC groups, 1:1 matching for BWs at treatment within 100 g was performed. The BW gains for the 7 days before treatment (pre-treatment week), the 7 days after treatment (first post-treatment week), and the period from 7 to 14 days after treatment (second post-treatment week) were compared between the IVB and PC groups.
Following 1:1 matching, 13 infants in both groups were enrolled in the analysis. The weekly BW gain for the first post-treatment week was significantly lower in the IVB group compared with the PC group (86 g vs. 145 g; P = 0.046), whereas the weekly BW gains for the pre-treatment week (173 g vs. 159 g; P = 0.71) and the second post-treatment week (154 g vs. 152 g; P = 0.73) were comparable between the two groups. The short-term inhibitive effect of IVB on BW gain was particularly observed in infants weighing less than 1500 g at treatment (<1500 g: 47 g vs. ≥1500 g: 132 g; P = 0.03).
IVB could have a short-term inhibitive effect on BW gain in infants with ROP, and this effect is more likely to occur in infants with a lower BW at the time of treatment.
评估玻璃体内注射贝伐单抗（IVB）治疗早产儿视网膜病变（ROP）后体重（BW）增加的短期效果。
这是一项回顾性 1:1 匹配病例对照研究。纳入 2010 年 4 月至 2019 年 12 月在滋贺医科大学医院接受 IVB 或光凝（PC）治疗的 ROP 婴儿。为了在 IVB 和 PC 组之间匹配治疗时的 BW，进行了治疗时 BW 相差 100 g 的 1:1 匹配。比较 IVB 和 PC 组治疗前 7 天（治疗前周）、治疗后 7 天（第一治疗后周）和治疗后 7-14 天（第二治疗后周）的 BW 增加量。
经过 1:1 匹配，两组各有 13 名婴儿纳入分析。与 PC 组相比，IVB 组第一治疗后周的每周 BW 增加量显著较低（86 g 比 145 g；P = 0.046），而治疗前周（173 g 比 159 g；P = 0.71）和第二治疗后周（154 g 比 152 g；P = 0.73）的 BW 增加量无差异。在治疗时 BW 较轻的婴儿（<1500 g：47 g 比 ≥1500 g：132 g；P = 0.03）中，IVB 对 BW 增加的短期抑制作用更为明显。
IVB 可能对 ROP 婴儿的 BW 增加有短期抑制作用，这种作用在治疗时 BW 较低的婴儿中更有可能发生。
