National Institute of Neurological Disorders and Stroke, Bethesda, MD 20892, USA.
National Institute of Neurological Disorders and Stroke, Bethesda, MD 20892, USA.
Behav Brain Res. 2022 Feb 15;419:113707. doi: 10.1016/j.bbr.2021.113707. Epub 2021 Dec 7.
Repetitive transcranial magnetic stimulation (rTMS) targeted to the hippocampal network via the inferior parietal cortex (HN-Stim) can strengthen hippocampal-cortical connectivity and improve episodic memory, offering a potential clinical intervention. However, acceptance of this technique has been tempered by the infrequent reproduction of findings in rTMS research on cognitive processes. We tested the reproducibility of the HN-Stim effect on episodic memory in our laboratory using different procedures from those previously published. We tested episodic memory in 29 participants before, one day, and one week after, three consecutive days of 20 Hz HN-Stim. Participants received stimulation targeted to either the area of inferior parietal cortex maximally connected to the left anterior hippocampus (HN-Stim; N = 14) or the vertex (control; N = 15), where we expected no effect. HN-Stim increased episodic memory performance one day, but not one week, after the last stimulation session. While failing to reproduce the lasting beneficial effect on memory found by others after five days of treatment, we found robust effects on behavior 24 h after treatment. HN-Stim is a safe and reliable means of enhancing episodic memory and may have potential for boosting learning and treating memory deficits.
经下顶叶皮层靶向海马网络的重复经颅磁刺激（rTMS）可增强海马-皮质连接，改善情景记忆，为临床干预提供了一种潜在的选择。然而，rTMS 对认知过程的研究结果很少得到重现，这限制了该技术的应用。我们使用与先前发表的不同程序，在实验室中测试了经下顶叶皮层靶向海马网络的 rTMS 对情景记忆的可重复性。我们在连续 3 天接受 20Hz 的 HN-Stim 刺激之前、之后的一天和一周，对 29 名参与者进行了情景记忆测试。参与者接受刺激的部位为与左前海马连接最密切的下顶叶皮层（HN-Stim；N=14）或顶点（对照组；N=15），我们预计后者不会产生效果。HN-Stim 刺激可在最后一次刺激后一天，但不在一周后提高情景记忆表现。虽然未能重现其他人在 5 天治疗后发现的对记忆的持久有益作用，但我们发现治疗后 24 小时行为上有明显的效果。HN-Stim 是一种安全可靠的增强情景记忆的方法，可能有增强学习和治疗记忆缺陷的潜力。
