Instituto de Nutrição, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil.
Instituto de Medicina Social, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil.
Nutr Res. 2021 Dec;96:1-8. doi: 10.1016/j.nutres.2021.10.002. Epub 2021 Nov 25.
Vitamin D insufficiency has been suggested as a risk factor for several metabolic disorders. The objective of the study was to investigate the association between serum 25 hydroxyvitamin D [25(OH)D] and metabolic health markers of Brazilian individuals with normal-weight, overweight or obesity. We hypothesized that serum 25(OH)D would be inversely associated with glycemic, lipid and inflammatory markers indicative of metabolic abnormality. Data of 511 individuals (33-79 years), recruited from a longitudinal investigation (Pró-Saúde Study), were analyzed cross-sectionally. Anthropometric, biochemical, body composition, socio-demographic and lifestyle data were collected. Based on body mass index (BMI; normal weight, overweight, obesity) and metabolic health (metabolically healthy (MH) and metabolically unhealthy (MU)) categories, the participants were classified into 6 phenotypes. Individuals having zero components of the metabolic syndrome were considered as "MH". MH obesity was frequent in 2.0% of the participants and 56.0% exhibited vitamin D insufficiency (<20 ng/mL). In the subgroups of the same BMI category, there were no significant differences in 25(OH)D concentrations between individuals classified as MH and MU. After adjustments (including %body fat and BMI), an inverse association was observed between 25(OH)D and visceral adipose tissue (B = -6.46, 95% confidence interval, CI: -12.87, -0.04), leptin (B = -0.09, 95% confidence interval, CI: -0.14, -0.03), insulin (B = -0.21, 95%CI: -0.34, -0.07), HOMA-IR (B = -0.06, 95%CI: -0.10, -0.02), triglycerides (B = -2.44, 95%CI: -3.66, -1.22), and TNF-α (B = -0.12, 95%CI: -0.24, -0.005) only in MU individuals. Our results indicate that the association of 25(OH)D concentrations with a favorable biochemical profile (glycemic, lipidic and inflammatory) seems to depend on the individual's overall metabolic health, suggesting more benefits from higher serum vitamin D in MU individuals, regardless of their adiposity.
维生素 D 不足被认为是多种代谢紊乱的危险因素。本研究的目的是探讨巴西正常体重、超重或肥胖个体血清 25 羟维生素 D [25(OH)D]与代谢健康标志物之间的关系。我们假设血清 25(OH)D 与血糖、血脂和炎症标志物呈负相关，这些标志物提示代谢异常。从一项纵向研究（Pro-Saúde 研究）中招募了 511 名（33-79 岁）参与者的数据进行横断面分析。收集了人体测量学、生化、身体成分、社会人口统计学和生活方式数据。根据体重指数（BMI；正常体重、超重、肥胖）和代谢健康（代谢健康（MH）和代谢不健康（MU））类别，将参与者分为 6 种表型。没有代谢综合征成分的个体被认为是“MH”。MH 肥胖在 2.0%的参与者中很常见，56.0%的参与者存在维生素 D 不足（<20ng/mL）。在相同 BMI 类别亚组中，MH 和 MU 个体之间的 25(OH)D 浓度没有显著差异。在调整（包括%体脂肪和 BMI）后，观察到 25(OH)D 与内脏脂肪组织（B=-6.46，95%置信区间，CI：-12.87，-0.04）、瘦素（B=-0.09，95%置信区间，CI：-0.14，-0.03）、胰岛素（B=-0.21，95%CI：-0.34，-0.07）、HOMA-IR（B=-0.06，95%CI：-0.10，-0.02）、甘油三酯（B=-2.44，95%CI：-3.66，-1.22）和 TNF-α（B=-0.12，95%CI：-0.24，-0.005）之间呈负相关，仅在 MU 个体中观察到。我们的结果表明，25(OH)D 浓度与有利的生化特征（血糖、血脂和炎症）之间的关联似乎取决于个体的整体代谢健康状况，这表明 MU 个体的血清维生素 D 水平更高，获益更多，而与肥胖无关。
