Annu Int Conf IEEE Eng Med Biol Soc. 2021 Nov;2021:2320-2325. doi: 10.1109/EMBC46164.2021.9630083.
Advancements in cancer research and treatment have highlighted the need for standardization and sharing of cancer stem cell (CSC) data to facilitate research transparency and to promote collaboration within the scientific community. Although previous applications have attempted to gather and disseminate these data, currently no platform organizes the heterogeneous CSC information into a harmonized project-based framework. The aim of our platform, ReMeDy, is to provide an intelligent informatics solution integrating diverse CSC characteristics, outcomes information, and omics data across clinical, preclinical and in vitro studies. These heterogeneous data streams are organized within a multi-modular framework, subjected to a stringent validation by using standardized ontologies, and stored in a searchable format. To test usefulness of our approach for capturing diverse data related to CSCs, we integrated data from 52 publicly-available CSC projects. We validated the robustness of the platform, by efficiently organizing diverse data elements, and demonstrated its potential for promoting future knowledge discovery driven by aggregation of published data. Next steps include expanding number of uploaded CSC projects and developing additional data visualization tools. The platform is accessible through https://remedy.mssm.edu/.
癌症研究和治疗的进展凸显了标准化和共享癌症干细胞 (CSC) 数据的需求，以促进研究透明度，并促进科学界内部的合作。尽管以前的应用程序已经尝试收集和传播这些数据，但目前没有平台将异质的 CSC 信息组织到一个协调的基于项目的框架中。我们的平台 ReMeDy 的目的是提供一个集成不同 CSC 特征、结果信息和组学数据的智能信息学解决方案，涵盖临床、临床前和体外研究。这些异质数据流在一个多模块框架中组织，通过使用标准化本体进行严格验证，并以可搜索的格式存储。为了测试我们的方法在捕获与 CSCs 相关的各种数据方面的有效性，我们整合了来自 52 个公开可用的 CSC 项目的数据。我们通过高效地组织各种数据元素来验证平台的稳健性，并展示了其通过聚合已发表数据促进未来知识发现的潜力。下一步包括增加上传的 CSC 项目数量和开发额外的数据可视化工具。该平台可通过 https://remedy.mssm.edu/ 访问。
