Annu Int Conf IEEE Eng Med Biol Soc. 2021 Nov;2021:2641-2646. doi: 10.1109/EMBC46164.2021.9630598.
Mild Cognitive Impairment (MCI) is the stage between the declining of normal brain function and the more serious decline of dementia. Alzheimer's disease (AD) is one of the leading forms of dementia. Although MCI does not always lead to AD, an early diagnosis of MCI may be helpful in finding those with early signs of AD. The Alzheimer's Disease Neuroimaging Initiative (ADNI) has utilized magnetic resonance imaging (MRI) for the diagnosis of MCI and AD. MCI can be separated into two types: Early MCI (EMCI) and Late MCI (LMCI). Furthermore, MRI results can be separated into three views of axial, coronal and sagittal planes. In this work, we perform binary classifications between healthy people and the two types of MCI based on limited MRI images using deep learning approaches. Specifically, we implement and compare two various convolutional neural network (CNN) architectures. The MRIs of 516 patients were used in this study: 172 control normal (CN), 172 EMCI patients and 172 LMCI patients. For this data set, 50% of the images were used for training, 20% for validation, and the remaining 30% for testing. The results showed that the best classification for one model was between CN and LMCI for the coronal view with an accuracy of 79.67%. In addition, we achieved 67.85% accuracy for the second proposed model for the same classification group.
轻度认知障碍 (MCI) 是正常大脑功能下降和更严重痴呆症之间的阶段。阿尔茨海默病 (AD) 是痴呆症的主要形式之一。虽然 MCI 不一定会导致 AD,但对 MCI 的早期诊断可能有助于发现那些有 AD 早期迹象的人。阿尔茨海默病神经影像学倡议 (ADNI) 已利用磁共振成像 (MRI) 来诊断 MCI 和 AD。MCI 可以分为两种类型:早期 MCI (EMCI) 和晚期 MCI (LMCI)。此外,MRI 结果可以分为轴向、冠状和矢状三个视图。在这项工作中,我们使用深度学习方法,基于有限的 MRI 图像,在健康人和两种 MCI 类型之间进行二分类。具体来说,我们实现并比较了两种不同的卷积神经网络 (CNN) 架构。本研究共使用了 516 名患者的 MRI:172 名对照正常 (CN)、172 名 EMCI 患者和 172 名 LMCI 患者。对于这个数据集,50%的图像用于训练,20%用于验证,其余 30%用于测试。结果表明,对于冠状视图,一种模型的最佳分类是 CN 和 LMCI,准确率为 79.67%。此外,我们为同一分类组的第二个提出的模型实现了 67.85%的准确率。
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