Bała M, Naparzewska A, Chojnacka-Wójcik E
Pol J Pharmacol Pharm. 1986 Mar-Apr;38(2):221-7.
Ten novel derivatives of 11H-indeno [1,2-b] quinolin-11-one (1-10) were synthesized and pharmacologically screened. All compounds showed analgesic activity. Anti-inflammatory activity was found only for alkylamine derivatives 1-6. The most active 10-ethylamine derivative 2 showed also ulcerogenic properties. The LD50/UD50 and UD50/ED50 values for compound 2 were less satisfactory than those for ibuprofen.
