Department of Cancer Biology, Thomas Jefferson University, Philadelphia, Pennsylvania.
Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania.
Cancer Res. 2022 Feb 15;82(4):523-533. doi: 10.1158/0008-5472.CAN-21-1756.
DNA-dependent protein kinase catalytic subunit (DNA-PKcs) is a pleiotropic protein kinase that plays critical roles in cellular processes fundamental to cancer. DNA-PKcs expression and activity are frequently deregulated in multiple hematologic and solid tumors and have been tightly linked to poor outcome. Given the potentially influential role of DNA-PKcs in cancer development and progression, therapeutic targeting of this kinase is being tested in preclinical and clinical settings. This review summarizes the latest advances in the field, providing a comprehensive discussion of DNA-PKcs functions in cancer and an update on the clinical assessment of DNA-PK inhibitors in cancer therapy.
DNA 依赖性蛋白激酶催化亚基（DNA-PKcs）是一种多功能蛋白激酶，在对癌症至关重要的细胞过程中发挥着关键作用。DNA-PKcs 的表达和活性在多种血液系统肿瘤和实体瘤中经常失调，并与不良预后密切相关。鉴于 DNA-PKcs 在癌症发展和进展中可能具有重要作用，因此正在临床前和临床环境中对该激酶进行靶向治疗。本综述总结了该领域的最新进展，全面讨论了 DNA-PKcs 在癌症中的作用，并更新了 DNA-PK 抑制剂在癌症治疗中的临床评估。
