沙特阿拉伯西南部唐氏综合征患者先天性心脏病的患病率。
Prevalence of congenital heart disease among patients with down syndrome in Southwestern Saudi Arabia.
机构信息
Department of Basic Medical Sciences, College of Medicine, University of Bisha, Bisha, Saudi Arabia.
Department of Family Medicine, College of Medicine, University of Bisha, Bisha, Saudi Arabia.
出版信息
Ann Afr Med. 2021 Oct-Dec;20(4):265-269. doi: 10.4103/aam.aam_57_20.
BACKGROUND
There is a paucity of data on the prevalence and pattern of congenital heart disease (CHD) among patients with Down syndrome (DS) in Bisha, Saudi Arabia. The aim of the study was to determine the prevalence and patterns of CHD in patients with DS and explore the association of participants' sex with CHD in DS patients.
METHODOLOGY
A total of 42 patients with confirmed DS were enrolled in the study. Relevant data were obtained from the patients' records. The spectrum of CHD was analyzed and classified accordingly. Pearson's Chi-square was used to determine the association of gender with CHD.
RESULTS
Approximately 81% of the study participants had CHD. The most common CHD was atrial septal defect (28.5%), followed by ventricular septal defect (25%), patent ductus arteriosus (16%), and atrioventricular septal defect (14.3%). No significant association was found between CHDs and sex.
CONCLUSION
The prevalence of CHD in the study group was consistent with reports from other regions of Saudi Arabia and globally. Participants' sex was not associated with the occurrence of CHD in DS patients in this study.
背景
在沙特阿拉伯比沙，关于唐氏综合征（DS）患者先天性心脏病（CHD）的患病率和模式的数据很少。本研究的目的是确定 DS 患者中 CHD 的患病率和模式，并探讨参与者的性别与 DS 患者 CHD 的关系。
方法
共纳入 42 例确诊为 DS 的患者。从患者的病历中获取相关数据。分析 CHD 的谱并进行相应分类。采用 Pearson 卡方检验确定性别与 CHD 的关系。
结果
研究参与者中约有 81%患有 CHD。最常见的 CHD 是房间隔缺损（28.5%），其次是室间隔缺损（25%）、动脉导管未闭（16%）和房室间隔缺损（14.3%）。CHD 与性别之间无显著关联。
结论
研究组 CHD 的患病率与沙特阿拉伯其他地区和全球的报告一致。在本研究中，参与者的性别与 DS 患者 CHD 的发生无关。
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