超越拉斯金方案：难治性慢性偏头痛的氯胺酮、利多卡因和其他疗法。
Beyond the Raskin Protocol: Ketamine, Lidocaine, and Other Therapies for Refractory Chronic Migraine.
机构信息
Department of Anesthesiology, Sidney Kimmel Medical College at Thomas Jefferson University, 111 South 11th Street, Suite 8290 Gibbon Building, Philadelphia, PA, 19107, USA.
Department of Neurology, Sidney Kimmel Medical College at Thomas Jefferson University, 900 Walnut St., Suite 200, Philadelphia, PA, 19107, USA.
出版信息
Curr Pain Headache Rep. 2021 Dec 11;25(12):77. doi: 10.1007/s11916-021-00992-x.
PURPOSE OF REVIEW
The purpose of this review is to discuss the available evidence and therapeutic considerations for intravenous drug therapy for refractory chronic migraine.
RECENT FINDINGS
In carefully monitored settings, the inpatient administration of intravenous lidocaine and ketamine can be successful in treating refractory chronic migraine. Many patients with refractory chronic migraine have experienced treatment failure with the Raskin protocol. The use of aggressive inpatient infusion therapy consisting of intravenous lidocaine or ketamine, along with other adjunctive medications, has become increasingly common for these patients when all other treatments have failed. There is a clear need for prospective studies in this population comprised of patients who have largely been excluded from other studies.
目的综述
本综述旨在讨论静脉药物治疗难治性慢性偏头痛的现有证据和治疗注意事项。
最近的发现
在经过精心监测的环境中，静脉内给予利多卡因和氯胺酮可以成功治疗难治性慢性偏头痛。许多难治性慢性偏头痛患者在使用 Raskin 方案治疗后都经历了治疗失败。对于所有其他治疗方法均失败的这些患者，越来越多地使用包括静脉内利多卡因或氯胺酮在内的强化住院输注治疗以及其他辅助药物。对于主要被排除在其他研究之外的患者人群，需要进行前瞻性研究。
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