Papavassiliou Kostas A, Papavassiliou Athanasios G
Department of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, Athens 11527, Athens, Greece.
Department of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, Athens 11527, Athens, Greece.
Biochim Biophys Acta Rev Cancer. 2022 Jan;1877(1):188667. doi: 10.1016/j.bbcan.2021.188667. Epub 2021 Dec 8.
Glioblastoma, also known as glioblastoma multiforme (GBM), is one of the most lethal human cancers, however, the molecular mechanisms driving GBM remain largely elusive. Recent studies have revealed that transcription factors are significantly involved in GBM biology. Transcription factors (TFs), which are proteins that bind DNA to regulate gene expression, have critical roles at focal points in signaling pathways, orchestrating many cellular processes, such as cell growth and proliferation, differentiation, apoptosis, immune responses, and metabolism. Dysregulated or mutated TFs are common in GBM, resulting in aberrant gene expression that promotes tumor initiation, progression, and resistance to conventional therapies. In the present Review, we focus on TFs that are implicated in GBM pathogenesis, highlighting their oncogenic or tumor suppressive functions and describing the molecular mechanisms underlying their effect on GBM cells. We also discuss their use as biomarkers for GBM prognosis and therapeutic response, as well as their targeting with drugs for GBM treatment. Deciphering the role of TFs in the biology of GBM will provide new insights into the pathological mechanisms and reveal novel biomarkers and therapeutic targets.
胶质母细胞瘤，也称为多形性胶质母细胞瘤（GBM），是最致命的人类癌症之一，然而，驱动GBM的分子机制在很大程度上仍然难以捉摸。最近的研究表明，转录因子在GBM生物学中起着重要作用。转录因子（TFs）是结合DNA以调节基因表达的蛋白质，在信号通路的关键点上发挥关键作用，协调许多细胞过程，如细胞生长和增殖、分化、凋亡、免疫反应和代谢。失调或突变的TFs在GBM中很常见，导致异常的基因表达，促进肿瘤的发生、发展以及对传统疗法的耐药性。在本综述中，我们重点关注与GBM发病机制相关的TFs，突出它们的致癌或抑癌功能，并描述它们对GBM细胞产生影响的分子机制。我们还讨论了它们作为GBM预后和治疗反应生物标志物的用途，以及针对它们开发GBM治疗药物的情况。解读TFs在GBM生物学中的作用将为病理机制提供新的见解，并揭示新的生物标志物和治疗靶点。
