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止痛药：非甾体抗炎药与艰难梭菌感染之间的相互作用

Pain killers: the interplay between nonsteroidal anti-inflammatory drugs and Clostridioides difficile infection.

作者信息

Soto Ocaña Joshua, Bayard Nile U, Zackular Joseph P

机构信息

Division of Protective Immunity, Children's Hospital of Philadelphia, Philadelphia, PA, United States; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States.

Division of Protective Immunity, Children's Hospital of Philadelphia, Philadelphia, PA, United States.

出版信息

Curr Opin Microbiol. 2022 Feb;65:167-174. doi: 10.1016/j.mib.2021.11.011. Epub 2021 Dec 8.

DOI:10.1016/j.mib.2021.11.011
PMID:34894543
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9058983/
Abstract

Clostridioides difficile is one of the leading causes of nosocomial infections worldwide. Increases in incidence, severity, and healthcare cost associated with C. difficile infection (CDI) have made this pathogen an urgent public health threat worldwide. The factors shaping the evolving epidemiology of CDI and impacting clinical outcomes of infection are not well understood, but involve tripartite interactions between the host, microbiota, and C. difficile. In addition to this, emerging data suggests an underappreciated role for environmental factors, such as diet and pharmaceutical drugs, in CDI. In this review, we discuss the role of nonsteroidal anti-inflammatory drugs (NSAIDs) and eicosanoids in CDI.

摘要

艰难梭菌是全球医院感染的主要原因之一。艰难梭菌感染（CDI）的发病率、严重程度及医疗成本不断上升，使这种病原体成为全球紧迫的公共卫生威胁。目前尚不清楚影响CDI流行病学演变及感染临床结局的因素，但这些因素涉及宿主、微生物群和艰难梭菌之间的三方相互作用。除此之外，新出现的数据表明，饮食和药物等环境因素在CDI中发挥着未被充分认识的作用。在本综述中，我们讨论非甾体抗炎药（NSAIDs）和类花生酸在CDI中的作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37b4/9058983/c068f0f5aaf0/nihms-1760342-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37b4/9058983/0f1060adaf88/nihms-1760342-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37b4/9058983/c068f0f5aaf0/nihms-1760342-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37b4/9058983/0f1060adaf88/nihms-1760342-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37b4/9058983/c068f0f5aaf0/nihms-1760342-f0002.jpg

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引用本文的文献

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本文引用的文献

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Antimicrobial Activity of Non-steroidal Anti-inflammatory Drugs on Biofilm: Current Evidence and Potential for Drug Repurposing.非甾体抗炎药对生物膜的抗菌活性：当前证据及药物再利用潜力
Front Microbiol. 2021 Jul 27;12:707629. doi: 10.3389/fmicb.2021.707629. eCollection 2021.
2
Proton-Pump Inhibitor Use and the Risk of Community-Associated Clostridium difficile Infection.质子泵抑制剂的使用与社区获得性艰难梭菌感染的风险。
Clin Infect Dis. 2021 Jun 15;72(12):e1084-e1089. doi: 10.1093/cid/ciaa1857.
3
NSAID-Gut Microbiota Interactions.
非甾体抗炎药-肠道微生物群的相互作用
Front Pharmacol. 2020 Aug 7;11:1153. doi: 10.3389/fphar.2020.01153. eCollection 2020.
4
From Nursery to Nursing Home: Emerging Concepts in Clostridioides difficile Pathogenesis.从托儿所到疗养院：艰难梭菌发病机制中的新兴概念。
Infect Immun. 2020 Jun 22;88(7). doi: 10.1128/IAI.00934-19.
5
A High-Fat/High-Protein, Atkins-Type Diet Exacerbates () Infection in Mice, whereas a High-Carbohydrate Diet Protects.高脂/高蛋白、阿特金斯式饮食会加剧小鼠的（）感染，而高碳水化合物饮食则具有保护作用。 （注：原文括号处内容缺失）
mSystems. 2020 Feb 11;5(1):e00765-19. doi: 10.1128/mSystems.00765-19.
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Misoprostol protects mice against severe Clostridium difficile infection and promotes recovery of the gut microbiota after antibiotic perturbation.米索前列醇可保护小鼠免受严重艰难梭菌感染，并促进抗生素扰乱后肠道微生物群的恢复。
Anaerobe. 2019 Aug;58:89-94. doi: 10.1016/j.anaerobe.2019.06.006. Epub 2019 Jun 17.
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