Key Laboratory of Eco-textiles, Ministry of Education, Jiangnan University, Wuxi 214122, People's Republic of China.
ACS Appl Mater Interfaces. 2021 Dec 22;13(50):59761-59771. doi: 10.1021/acsami.1c20548. Epub 2021 Dec 12.
Underwater adhesives with efficient, selective, and repeatable adhesion are urgently needed for biomedical applications. Catechol-containing hydrogel adhesives have aroused much interest, but the design of specific underwater adhesives to biotic surfaces is still a challenge. Here we report a facile way that recapitulates the adhesion mechanism of mussel and sea gooseberry for the development of robust and specific hydrogel adhesives. With an exquisite design of chemical bonding, catechol chemistry, and electrostatic interaction, the hydrogel consisting of poly(acrylic acid) grafted with -hydroxysuccinimide ester (PAA-NHS ester), tea polyphenol (TP), chitosan (CS), and Al exhibited fast, specific, and repeatable underwater adhesion to various biological tissues, such as porcine skin, intestine, liver, and shrimp. Furthermore, nanofibers-hydrogel composite (NF-HG) was prepared via the wicking effect of curcumin-loaded electrospun nanofibers. The NF-HG exhibited pH-responsive color changing properties, sustained drug release, and good cell viability, which made it suitable as a novel wound healing material. This strategy may provide great inspiration for designing multifunctional specific underwater adhesives.
用于生物医学应用的具有高效、选择性和可重复粘附的水下胶粘剂是迫切需要的。含儿茶酚的水凝胶胶粘剂引起了广泛的关注，但设计针对生物表面的特定水下胶粘剂仍然是一个挑战。在这里，我们报告了一种简单的方法，该方法再现了贻贝和海红果的粘附机制，以开发强大且特定的水凝胶胶粘剂。通过化学结合、儿茶酚化学和静电相互作用的精巧设计，由接枝了 - 羟基琥珀酰亚胺酯（PAA-NHS 酯）、茶多酚（TP）、壳聚糖（CS）和 Al 的聚丙烯酸（PAA）组成的水凝胶表现出快速、特定和可重复的水下粘附各种生物组织，如猪皮、肠、肝和虾。此外，通过负载姜黄素的静电纺纳米纤维的吸液作用制备了纳米纤维-水凝胶复合材料（NF-HG）。NF-HG 表现出 pH 响应变色特性、持续药物释放和良好的细胞活力，使其适合用作新型伤口愈合材料。该策略可能为设计多功能特定水下胶粘剂提供重要启示。
