Rahman A, Joher A, Neefe J R
Br J Cancer. 1986 Sep;54(3):401-8. doi: 10.1038/bjc.1986.190.
We have shown that doxorubicin entrapped in cardiolipin liposomes retain antitumour efficacy in mice but had diminished cardiac uptake and cardiotoxicity. Such liposomes are preferentially taken up by spleen. In a previous study we showed that a single dose of liposomal doxorubicin is not more toxic than free doxorubicin with regard to immunologic parameters including generation of cytotoxicity for histocompatibility alloantigens and mitogenic responsiveness. In the present study, we have explored clinically relevant multiple dosing at weekly intervals, 2, 3, or 4 times. Again, despite splenic localization of liposomal doxorubicin, the depressive effect on these immunological parameters is not greater than the effect of free drug, and, in addition, the damage is repaired earlier.
我们已经表明，包裹在心肌磷脂脂质体中的阿霉素在小鼠体内仍保留抗肿瘤功效，但心脏摄取减少且心脏毒性降低。此类脂质体优先被脾脏摄取。在先前的一项研究中我们表明，就免疫参数而言，包括对组织相容性同种异体抗原产生细胞毒性和促有丝分裂反应性，单剂量脂质体阿霉素的毒性并不比游离阿霉素更大。在本研究中，我们探索了每周间隔2次、3次或4次的临床相关多次给药情况。同样，尽管脂质体阿霉素在脾脏定位，但对这些免疫参数的抑制作用并不比游离药物的作用更大，此外，损伤修复得更早。
