尼日利亚镰状细胞贫血女性的卵巢储备：一项横断面研究。
Ovarian reserve in nigerian women with sickle cell anaemia: a cross- sectional study.
机构信息
Department of Obstetrics and Gynaecology, Lagos University Teaching Hospital, Idi-Araba Lagos, Nigeria P.M.B. 12003, Surulere, Lagos, Nigeria.
Department of Obstetrics and Gynaecology, College of Medicine University of Lagos, Idi-Araba, Lagos, Nigeria.
出版信息
J Ovarian Res. 2021 Dec 11;14(1):174. doi: 10.1186/s13048-021-00927-5.
INTRODUCTION
Sickle cell disease is the most common monogenetic disorder worldwide. There have been reports of endocrine dysfunction and gonadal failure among affected individuals, especially in males. The findings on ovarian reserve and failure in women with sickle anaemia have been inconsistent.
AIM AND OBJECTIVE
The aim of this study was to determine and compare the ovarian reserve of Nigerian women with and without sickle cell anaemia attending a University Teaching Hospital.
STUDY DESIGN
This cross-sectional study was carried out at the Adult Sickle Cell Clinic and the Community Health Clinic of the Lagos University Teaching Hospital.
METHODOLOGY
A total of 166 participants who met the selection criteria, were recruited for the study. The study population consisted of two groups of women matched for age: 83 women with HbSS and 83 women with HbAA. The haemoglobin phenotype of each participant was determined on alkaline electrophoresis (pH 8.4) before analysis. Serum Anti-Mullerian Hormone (AMH) was determined using Enzyme-linked immunosorbent assay (ELISA) method (Calbiotech Inc. USA, Catalog no AM448T).
RESULTS
The mean ± SD of serum AMH level in women with HbSS was 3.64 ± 0.65 ng/mL and was lower than that of women with HbAA 7.35 ±1.19 ng/mL (p < 0.001). Serum AMH negatively correlated with age in both study groups (HbAA and HbSS). Also, a significant negative correlation was found between serum AMH and BMI in women with HbAA.
CONCLUSION
The study showed diminished ovarian reserve in women with HbSS when compared to age-matched women with HbAA.
简介
镰状细胞病是全球最常见的单基因疾病。受影响的个体，尤其是男性，存在内分泌功能障碍和性腺功能衰竭的报道。关于镰状细胞贫血女性的卵巢储备和衰竭的研究结果并不一致。
目的和目标
本研究旨在确定并比较在一所教学医院就诊的镰状细胞贫血和非镰状细胞贫血的尼日利亚女性的卵巢储备情况。
研究设计
这项横断面研究在拉各斯大学教学医院的成人镰状细胞诊所和社区卫生诊所进行。
方法
共招募了 166 名符合入选标准的参与者参加了这项研究。研究人群由两组年龄匹配的女性组成：83 名 HbSS 女性和 83 名 HbAA 女性。在分析之前，使用碱性电泳（pH 8.4）确定每个参与者的血红蛋白表型。使用酶联免疫吸附测定（ELISA）法（Calbiotech Inc. USA，目录号 AM448T）测定血清抗苗勒管激素（AMH）。
结果
HbSS 女性的血清 AMH 水平的平均值±标准差为 3.64±0.65ng/mL，低于 HbAA 女性的 7.35±1.19ng/mL（p<0.001）。血清 AMH 在两个研究组（HbAA 和 HbSS）中均与年龄呈负相关。此外，在 HbAA 女性中，血清 AMH 与 BMI 之间存在显著的负相关。
结论
与年龄匹配的 HbAA 女性相比，HbSS 女性的卵巢储备减少。
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