Instituto de Investigación Biomédica de Málaga (IBIMA), Málaga, Spain; UGC de Reumatología, Hospital Regional Universitario de Málaga, Málaga, Spain.
Instituto de Investigación Biomédica de Málaga (IBIMA), Málaga, Spain; UGC de Reumatología, Hospital Regional Universitario de Málaga, Málaga, Spain.
Reumatol Clin (Engl Ed). 2022 Nov;18(9):531-537. doi: 10.1016/j.reumae.2021.06.002. Epub 2021 Dec 8.
Sarcopenia is a major cause of morbidity in rheumatoid arthritis patients. Our purpose was to determine whether polyautoimmunity is associated with sarcopenia and alterations in whole body composition in patients with rheumatoid arthritis (RA).
We performed a cross-sectional observational study of a series of cases of RA. All patients were recruited consecutively from a rheumatology clinic. Body composition by dual-energy x-ray absorptiometry (DEXA) was assessed. The variables of interest were polyautoimmunity (RA associated with other autoimmune diseases), sarcopenia, fat mass, and body mass index (BMI). Other variables included were clinical-analytical and inflammatory cytokines and adipokines. The relationship between sarcopenic obesity and the presence of polyautoimmunity was studied using multivariate analysis.
Of the 94 patients with RA included in the study, 15 (16%) had polyautoimmunity. A total of 23 patients with RA (24.5%) had sarcopenia, which was more prevalent in patients with polyautoimmunity than in patients without polyautoimmunity (46.7% vs 20.3%; p = .029). Sarcopenia was not associated with body fat content (p = .870) or with BMI (p = .998). The multivariate analysis showed the factors associated with polyautoimmunity in RA to be sarcopenia (odds ratio [95% CI], 4.80 [1.49-13.95]), BMI (1.18 [1.04-1.35]), and resistin (1.249 [1.01-1.53]).
Sarcopenia and obesity were more prevalent in patients with RA and polyautoimmunity. Resistin values were also higher in this group than in patients with RA without polyautoimmunity.
肌少症是类风湿关节炎患者发病和致残的主要原因。本研究旨在探讨多系统自身免疫性疾病是否与类风湿关节炎（RA）患者的肌少症及全身成分改变相关。
我们进行了一项 RA 系列病例的横断面观察性研究。所有患者均连续从风湿病门诊招募。采用双能 X 线吸收法（DEXA）评估身体成分。研究的相关变量包括多系统自身免疫性疾病（RA 合并其他自身免疫性疾病）、肌少症、脂肪量和体重指数（BMI）。其他变量包括临床分析、炎症细胞因子和脂肪因子。采用多变量分析研究肌少症性肥胖与多系统自身免疫性疾病的关系。
本研究纳入的 94 例 RA 患者中，15 例（16%）患有多系统自身免疫性疾病。共有 23 例 RA 患者（24.5%）患有肌少症，多系统自身免疫性疾病患者的肌少症患病率高于无多系统自身免疫性疾病患者（46.7%比 20.3%；p=0.029）。肌少症与体脂含量（p=0.870）或 BMI（p=0.998）无关。多变量分析显示，与 RA 多系统自身免疫性疾病相关的因素为肌少症（优势比[95%可信区间]，4.80[1.49-13.95]）、BMI（1.18[1.04-1.35]）和抵抗素（1.249[1.01-1.53]）。
RA 合并多系统自身免疫性疾病患者更易出现肌少症和肥胖。与无多系统自身免疫性疾病的 RA 患者相比，该组患者的抵抗素水平也更高。
