Division of Endocrinology, Department of Pediatrics, Children's Hospital of Pittsburgh of UPMC, University of Pittsburgh School of Medicine, Pittsburgh, PA 15224, USA.
Division of Genetic and Genomic Medicine, Department of Pediatrics, Children's Hospital of Pittsburgh of UPMC, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Biochim Biophys Acta Gen Subj. 2022 Feb;1866(2):130066. doi: 10.1016/j.bbagen.2021.130066. Epub 2021 Dec 9.
Mitochondria-derived peptides (MDPs) are bioactive peptides encoded by and secreted from the mitochondria. To date, a few MDPs including humanin, MOTS-c and SHLP1-6, and their diverse biological functions have been identified. The first and most studied MDP is humanin, a 24-amino-acid poly peptide. It was first identified in 2001 in the surviving neurons of patient with Alzheimer's disease, and since then has been well characterized for its neuro-protective effect through inhibition of apoptosis. Over the past two decades, humanin has been reported to play critical roles in aging as well as multiple diseases including metabolic disorders, cardiovascular diseases, and autoimmune disease. Humanin has been shown to modulate multiple biological processes including autophagy, ER stress, cellular metabolism, oxidative stress, and inflammation. A role for humanin has been shown in a wide range of cardiovascular diseases, such as coronary heart disease, atherosclerosis, and myocardial fibrosis. In this minireview, we will summarize the literature demonstrating a role for humanin in cardio-protection following myocardial ischemia-reperfusion induced injury and the potential mechanisms that mediate it.
线粒体衍生肽（MDPs）是由线粒体编码并分泌的生物活性肽。迄今为止，已经鉴定出几种 MDP，包括 humanin、MOTS-c 和 SHLP1-6，以及它们的多种生物学功能。第一个也是研究最多的 MDP 是 humanin，一种 24 个氨基酸的多肽。它于 2001 年在阿尔茨海默病患者的存活神经元中首次被发现，此后因其通过抑制细胞凋亡发挥神经保护作用而得到了很好的描述。在过去的二十年中，humanin 被报道在衰老以及包括代谢紊乱、心血管疾病和自身免疫性疾病在内的多种疾病中发挥关键作用。humanin 已被证明调节多种生物学过程，包括自噬、内质网应激、细胞代谢、氧化应激和炎症。humanin 在广泛的心血管疾病中发挥作用，例如冠心病、动脉粥样硬化和心肌纤维化。在这篇综述中，我们将总结文献证明 humanin 在心肌缺血再灌注诱导损伤后的心脏保护作用及其介导的潜在机制。
