Catechin/β-cyclodextrin complex modulates physicochemical properties of pre-gelatinized starch-based orally disintegrating films.

The study aimed to develop pre-gelatinized starch-based orally disintegrating films (ODFs) containing catechin/β-cyclodextrin (CAT/β-CD) complex and to evaluate the influence of the complex on the physicochemical properties of the ODFs. SEM images showed that a compacter and more homogeneous ODFs were formed due to interactions between starch matrix and CAT/β-CD. FTIR spectra demonstrated that the interactions between starches or starch and CAT/β-CD were enhanced by hydrogen bonds. Thermal stability of ODFs was improved by incorporating CAT/β-CD, its peak decomposition temperature was enhanced from 310.74 to 321.83 °C. Tensile strength was increased from 11.597 ± 0.153 to 22.172 ± 0.752 MPa, while elongation at break decreased by from 11.233% ± 1.079% to 3.633% ± 0.058%. The prepared ODFs have an acceptable in vitro disintegration time, which were between 9.03 ± 0.79 s and 42.23 ± 1.76 s. Antimicrobial test showed that ODFs incorporating CAT/β-CD inhibited the growth of S. aureus and S. mutans successfully. The limited release of CAT molecules from the ODFs was also found. In addition, the ODFs have excellent antioxidant capacity. Its antioxidant activity remained at around 70% after 28 days of storage. The study indicated that the combination of ODFs and β-CD complex have a high potential for the delivery of natural active ingredients.