Ptak W, Rewicka M, Gryglewski A, Bielecka J
Int Arch Allergy Appl Immunol. 1986;81(2):136-40. doi: 10.1159/000234122.
Contact sensitization induces two different kinds of T cells (both Ly 1) that act in sequence to produce upon challenge with antigen a classical 24-hour local skin swelling reaction. One of these cells produces an antigen-specific factor. It has been suggested that it sensitizes mast cells, similar to IgE antibody, and causes them to release vasoactive amines in the presence of antigen. This results in an early (2-hour) swelling reaction. Increased vascular permeability facilitates the entry of the second, lymphokine-producing Ly 1 cell into the site of reaction to elicit the classical 24-hour delayed-type hypersensitivity reaction. In alloxan diabetic mice, contact sensitivity reactions are reduced significantly, and our experiments show that insulin deficiency affects only the activity of the late acting, lymphokine-producing cell and leaves the factor-producing cell responsible for the early swelling reaction unaffected. Our experiments demonstrate that insulin deficiency has different effects on distinct subpopulations of T lymphocytes.
接触致敏会诱导出两种不同类型的T细胞（均为Ly 1），它们依次发挥作用，在受到抗原激发时产生典型的24小时局部皮肤肿胀反应。其中一种细胞会产生一种抗原特异性因子。有人提出，它类似于IgE抗体，使肥大细胞致敏，并导致它们在抗原存在的情况下释放血管活性胺。这会导致早期（2小时）肿胀反应。血管通透性增加有利于第二种产生淋巴因子的Ly 1细胞进入反应部位，引发典型的24小时迟发型超敏反应。在四氧嘧啶糖尿病小鼠中，接触敏感性反应显著降低，我们的实验表明，胰岛素缺乏仅影响后期起作用的产生淋巴因子的细胞的活性，而负责早期肿胀反应的产生因子的细胞不受影响。我们的实验证明，胰岛素缺乏对T淋巴细胞的不同亚群有不同的影响。
