α-酮缩醛的直接不对称还原胺化反应：合成各种α-官能化胺的平台。
Direct asymmetric reductive amination of α-keto acetals: a platform for synthesizing diverse α-functionalized amines.
机构信息
Shenzhen Key Laboratory of Small Molecule Drug Discovery and Synthesis, Southern University of Science and Technology, Shenzhen 518055, China.
Department of Chemistry and State Key Laboratory of Synthetic Chemistry, The University of Hong Kong, Hong Kong, China.
出版信息
Chem Commun (Camb). 2022 Jan 6;58(4):513-516. doi: 10.1039/d1cc06601c.
We report an efficient and straightforward method to synthesize enantio-enriched -unprotected α-amino acetals ruthenium-catalyzed direct asymmetric reductive amination. The α-amino acetal products are versatile and valuable platform molecules that can be converted to the corresponding α-amino acids, amino alcohols, and other derivatives by convenient transformations.
我们报道了一种高效、直接的方法，通过钌催化的不对称还原胺化反应合成对映体富集的 -未保护的α-氨基缩醛。α-氨基缩醛产物是多功能且有价值的平台分子，可以通过方便的转化转化为相应的α-氨基酸、氨基醇和其他衍生物。
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