Department of Surgery, Cleveland Clinic, Cleveland, Ohio, USA.
Department of Surgery, Brigham and Women Hospital, Boston, Massachusetts, USA.
J Surg Oncol. 2022 Jan;125(1):7-16. doi: 10.1002/jso.26722.
Surgical trials in breast cancer have catalyzed contemporary trial design for solid organ cancers and are a prime example of surgeons taking the lead in clinical trial design. Surgeons have lead trials that have improved patient outcomes and quality of life without sacrificing oncologic safety. We have evolved from radical mastectomy to breast conservation and sentinel node biopsy. Contemporary trial design in breast cancer now focus on personalizing care based on tumor genomics.
乳腺癌的外科临床试验推动了实体瘤癌症的当代临床试验设计，是外科医生在临床试验设计中发挥主导作用的一个主要范例。外科医生主导的试验提高了患者的治疗效果和生活质量，同时又不牺牲肿瘤安全性。我们已经从根治性乳房切除术发展到保乳手术和前哨淋巴结活检。目前乳腺癌的临床试验设计侧重于根据肿瘤基因组学来实现个体化治疗。
