Rister M, Roth B, Skopnik H, Liertz K P
Klin Padiatr. 1986 Jul-Aug;198(4):316-20. doi: 10.1055/s-2008-1033879.
The evaluation of delayed cutaneous hypersensitivity by using a standardized test system offers an assessment of cell-mediated immunity. The number and diameter of positive responses induced by seven antigens result in a score. The study included 21 healthy children, 20 children with bacterial infections as well as 20 patients with chronic renal insufficiency. In addition, 16 children with cystic fibrosis were also studied. No differences in the skin reactions was found in children with bacterial infections, showing a score of 13 +/- 6 mm. But children with cystic fibrosis or with renal insufficiency exhibited a severe impaired cell-mediated immunity. To what extent the alteration of cell-mediated immunity affects the course of the various diseases, has to be investigated by further prospective studies.
通过使用标准化测试系统评估迟发型皮肤超敏反应可对细胞介导的免疫进行评估。由七种抗原诱导产生的阳性反应的数量和直径得出一个分数。该研究纳入了21名健康儿童、20名患有细菌感染的儿童以及20名慢性肾功能不全患者。此外，还对16名患有囊性纤维化的儿童进行了研究。患有细菌感染的儿童的皮肤反应无差异，得分为13±6毫米。但患有囊性纤维化或肾功能不全的儿童表现出严重受损的细胞介导免疫。细胞介导免疫的改变在多大程度上影响各种疾病的进程，有待进一步的前瞻性研究进行调查。
