Pumar José M, Sucasas Paula, Mosqueira Antonio, Vega Pedro, Murias Eduardo
Catedra de Neurorradiología Intervencionista, Universidad de Santiago de Compostela, Santiago de Compostela, Spain.
Neuroradiology Department, Hospital Clínico Universitario, Santiago de Compostela, Spain.
Front Neurol. 2021 Nov 26;12:744962. doi: 10.3389/fneur.2021.744962. eCollection 2021.
This study aimed to evaluate the angiographic and clinical outcome, with an emphasis on long-term follow-up, of the LEO Plus stent for wide-neck intracranial aneurysms treated in a single center. We retrospectively examined a prospectively maintained database of patients treated with LEO Plus devices between January 2004 and December 2016. Data regarding patient demographics, aneurysm characteristics, and technical procedures were analyzed. Angiographic and clinical findings were recorded during the procedure and followed up over a period of at least 5 years. We identified 101 patients with 116 aneurysms. In 16 patients, the stent could not safely be placed. Thus, a total of 97 LEO Plus devices were implanted in 97 aneurysms of 85 patients. Adverse events (acute and delayed) were observed in 21.6% of cases (17/85), and most were resolved (70.6%; 12/17). Moreover, 5 years after the procedure, total morbidity and mortality were 2.3% (2/85) and 3.5% (3/85), respectively. Long-term imaging follow-up showed complete occlusions, neck remnants, and residual aneurysms in 73.1% (57/78), 14.1% (11/78), and 12.8% (10/78) of cases, respectively. Long-term results of treatment of brain aneurysms with LEO stent show high rates of adequate and stable occlusion over time, with acceptable morbidity and mortality.
本研究旨在评估单中心使用LEO Plus支架治疗宽颈颅内动脉瘤的血管造影结果和临床结局，重点是长期随访。我们回顾性研究了一个前瞻性维护的数据库，该数据库包含2004年1月至2016年12月期间接受LEO Plus装置治疗的患者。分析了患者人口统计学、动脉瘤特征和技术操作等数据。在手术过程中记录血管造影和临床结果，并进行至少5年的随访。我们确定了101例患者的116个动脉瘤。其中16例患者无法安全放置支架。因此，共对85例患者的97个动脉瘤植入了97个LEO Plus装置。21.6%（17/85）的病例观察到不良事件（急性和延迟性），大多数不良事件得到解决（70.6%；12/17）。此外，术后5年，总发病率和死亡率分别为2.3%（2/85）和3.5%（3/85）。长期影像学随访显示，分别有73.1%（57/78）、14.1%（11/78）和12.8%（10/78）的病例出现完全闭塞、颈部残留和残余动脉瘤。使用LEO支架治疗脑动脉瘤的长期结果显示，随着时间推移，充分且稳定闭塞的比例较高，发病率和死亡率可接受。
