Mungai Lucy N W, Mohammed Zanuba, Maina Michuki, Anjumanara Omar
Department of Paediatrics, University of Nairobi, Nairobi, Kenya.
KEMRI Wellcome Trust Research Programme, Kilifi, Kenya.
J Nutr Metab. 2021 Dec 2;2021:6335681. doi: 10.1155/2021/6335681. eCollection 2021.
Vitamin D is an important hormone that is known for the regulation of calcium and phosphate metabolism. Vitamin D deficiency leads to rickets in children and osteoporosis in adults leading to poor bone mineralisation and can also lead to serious dental complications in the same population. Recent studies have shown vitamin D to work as a hormone needed not only in bone and teeth but also in other body organs from intrauterine life up to old age. It has been demonstrated that Vitamin D has various effects on biological processes that deal with cell growth, differentiation, cell death, immune regulation, DNA stability, and neuronal growth. Despite being readily formed in the body through the intervention of the sun, patients are still found to have low vitamin D levels. We review studies done to show how vitamin D works.
维生素D是一种重要的激素，以调节钙和磷代谢而闻名。维生素D缺乏会导致儿童佝偻病和成人骨质疏松症，导致骨矿化不良，还会在同一人群中引发严重的牙齿并发症。最近的研究表明，维生素D作为一种激素，不仅在骨骼和牙齿中发挥作用，从子宫内生命到老年，在身体的其他器官中也发挥作用。已经证明，维生素D对涉及细胞生长、分化、细胞死亡、免疫调节、DNA稳定性和神经元生长的生物学过程有多种影响。尽管通过阳光照射在体内很容易形成维生素D，但仍发现患者的维生素D水平较低。我们回顾了相关研究，以展示维生素D的作用机制。
